摘要
目的探讨β-族溶血性链球菌(GBS)感染与胎膜早破的关系及母儿预后的影响。方法选择胎膜早破(PROM)292例和200例正常妊娠作对照,取宫颈-阴道分泌物进行GBS培养,对GBS阳性的胎膜早破孕妇的羊水作白介素-6测定,并随机选择20例GBS阴性的胎膜早破孕妇作比较,并比较母儿预后。结果胎膜早破孕妇宫颈-阴道分泌物GBS阳性率(14%)明显高于正常组(6.0%)(P<0.05),未足月胎膜早破孕妇122例GBS阳性率(17.2%)明显高于足月胎膜早破孕妇170例(11.8%)(P<0.05),GBS阳性的胎膜早破孕妇羊水白介素-6(IL-6)176.6±82.4ng/L明显高于GBS阴性的胎膜早破孕妇的122.7±59.3ng/L(P<0.05),GBS阳性胎膜早破孕妇的分娩距破膜时间<24h、胎儿窘迫、低体重儿的发生率较阴性孕妇高(P<0.05),产褥感染、新生儿感染发生率较阴性孕妇高,但无统计学意义。结论GBS感染可引起胎膜早破的发生及影响母儿预后。
Objective: To explore the relation between beta- hemolytic streptococci (GBS) and premature rupture of membranes ( PROM ) and influence in the health of pregnant women and their newborns. Methods : The cervical and vaginal secretion samples of premature rupture of membranes (PROM) women ( study group, 292 cases), and without PROM women (control group, 200 eases) were tested for GBS examination. Then the amniotic fluid was taken from GBS - positive PROM women and 20 cases of GBS - negative PROM women for examination of IL - 6. Results : The GBS infection rates in study group ( 14% ) were significantly higher than those in control group (6.0%), and the GBS infection rates in Preterm PROM ( 17. 2% ) were significantly higher than those in Full - term PROM ( 11.8% ) ( P 〈 0. 05), and IL - 6 in GBS - positive PROM women were added 176. 6 ± 82. 4ng/L than those in GBS- negative PROM women122. 7± 59.3ng/L ( P 〈 0. 05 ), GBS positive premature rupture membranes women whose incidences of time of less than twenty - four hours from rupture membrane to labor and fetaldistress, low birth weight were all higher than those in the GBS - negative women ( P 〈 0.05 ), It was also found that there were more puerperal infection, neonatal infection in GBS - positive women than in the GBS -negative women, however nostatistically significant difference. Conclusions: GBS infection can cause the occurrence of premature rupture of membranes (PROM) and GBS is severe enough to threat the health of pregnant women and their newborns.
出处
《中国优生与遗传杂志》
2009年第9期68-69,共2页
Chinese Journal of Birth Health & Heredity
基金
温州科技局立项科题(编号Y20080225)
关键词
胎膜早破
β-族溶血性链球菌
白介素-6
Premature rupture of membranes (PROM)
Beta - hemolytic streptococci (GBS)
IL - 6