摘要
目的：探讨细胞信号传导分子Ｐ３６与肝细胞癌发生、发展的关系。方法：采用ＳＰ免疫细胞化学方法，检测７０例肝细胞癌组织中Ｐ３６的分布和表达。结果：４０例Ｐ３６表达阳性，占５７．１％，阳性物质主要位于胞浆内，少数位于胞核或胞膜上。肿瘤分化越差，其阳性染色越强。Ｐ３６在ＨＢｘＡｇ阳性病例中的检出率高于ＨＢｘＡｇ阴性病例中的检出率（Ｐ＜０．０５）。结论：Ｐ３６有可能成为判定肝细胞癌恶性程度的标记物，Ｐ３６的异常表达与肝细胞癌的发生、发展关系密切。
Objective: To explore the relationship between cell signal conducting molecule P36 and occurrence and development of hepatocellular carcinoma. Methods: SP immunocytochemical techniques were used to detect the distribution and expression of P36 in 70 cases of hepatocellular carcinoma. Results: The findings showed the total positive rate of P36 was 57.1%(40/70), and P36 located mainly in cytoplasm with a small amount in cellular membrane and nuclei. In the patients whose tumors differentiated more poorly,the positive colorations were stronger. Tumor tissues conceived higher positive rate for P36 in the positive HBxAg cases as compared with the negative HBxAg cases. Conclusion: P36 is an essential marker for judging the malignance of hepatocellular carcinoma,and closely related to transformation of hepatocellular carcinoma.High expression of P36 may be related to the infection of HBV.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1998年第4期314-315,共2页
Academic Journal of Second Military Medical University
关键词
肝肿瘤
信号传导分子
肝细胞癌
细胞信号
hepatoma
cell signal conducting molecule
immunohistochemistry
