摘要
中枢神经系统脱髓鞘疾病以多发性硬化(multiple sclerosis,MS)和视神经脊髓炎(neuromyelitis optica,NMO)最常见。除常规治疗外,干扰素、他汀类药物、雌激素等已被作为MS患者缓解期的治疗用药,而低剂量激素、免疫抑制剂被推荐用于NMO患者缓解期的维持治疗。对常规治疗反应不好的MS或NMO患者,可尝试使用新型免疫调节药物或淋巴细胞去除等疗法。今后需要加强大样本的临床随机对照研究以准确评估各种新药的疗效及安全性。
Autoimmune demyelinating diseases in central nervous system mainly include multiple sclerosis（MS） and neuromyelitis optica（NMO）.Besides routine therapies,drugs as statins,interferon and estrogen have been applied during the paracmastic period of MS patients;while low dose of steroid and immunosuppressive agent have been recommended as maintenance during the paracmastic period of NMO patients.MS or NMO patients who respond poorly to routine therapies could choose alternative therapies as new types of immunomodulatory agents or lymphocytapheresis.Large-sample clinical randomized control study will be required to evaluate the new drugs＇ effectiveness and safety in the future.
出处
《实用医院临床杂志》
2009年第3期5-8,共4页
Practical Journal of Clinical Medicine
关键词
脱髓鞘疾病
多发性硬化
视神经脊髓炎
治疗
Demyelinating diseases
Multiple sclerosis
Optical neuromyelitis
Treatment
