摘要
目的比较度洛西汀与氟西汀治疗精神分裂症后抑郁的临床疗效和安全性。方法46例诊断为精神分裂症后抑郁的患者随机分为两组,分别用度洛西汀和氟西汀治疗6周,采用汉密尔顿抑郁量表(HAMD),简明精神病评定量表(BPRS)阴性症状量表(SANS)及副反应量表(TESS)于治疗前和治疗后2、4、6周末分别评定疗效和副反应症状。结果度洛西汀和氟西汀组HAMD评分差异无显著性,副反应症状差异也无显著性。结论度洛西汀治疗精神分裂症后抑郁的临床疗效于与氟西汀相当。安全性高,不良反应轻微,可以用于精神分裂症后抑郁的治疗。
Objective To compare the clinical curative effect and the safety of duloxetine and fuloxetine in treating post - schizo- phrenia depression. Methods 46 cases with post - schizophrenia depression were randomly divided into 2 groups and treated with duloxetine and fuloxetine respectively for 6 weeks; HAMD, BPRS, SANS and TESS were used before treatment and 2,4 and weeks after treatment to evaluate the curative effect and side - effect symptoms. Result There existed no significant difference in the scores of HAMD between the 2 groups as well as the side - effect symptoms. Conclusions Duloxetine and fuloxetine share the same curative effect in the treatment of post - schizophrenia depression with high safety and slight side - effect.
出处
《西南军医》
2009年第5期840-841,共2页
Journal of Military Surgeon in Southwest China
关键词
度洛西汀
氟西汀
精神分裂症后抑郁
duloxetine fuloxetine post - schizophrenia depression
