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RNAi在丙型肝炎基因治疗中的研究进展

Progress of gene therapy in hepatitis C by RNAi
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摘要 RNA干扰(RNA interference,RNAi)技术是通过小干扰RNA(siRNA)降解具有序列同源性的mRNA分子而实现的基因表达沉默。目前将RNAi应用于丙型肝炎基因治疗的研究备受关注。siRNA能够有效抑制病毒复制和蛋白表达。但要将该技术应用于丙型肝炎临床治疗仍然存在很多问题。 RNA interference （RNAi） is an phenomenon in which small interfering RNA siRNA） degrades the target RNA molecule in a sequence-specific manner to silence the gene expres, sion. In recent years, RNAi is the focus in the gene therapy for hepatitis C. The siRNA iseffective in inhibiting virus replication and protein expression, but there are many difficulties in clinic therapy for hepatitis C by RNAi.
作者 资源 冯德云
机构地区 中南大学基础医学院病理系
出处 《国际病理科学与临床杂志》 CAS 2009年第4期346-349,共4页 Journal of International Pathology and Clinical Medicine
关键词 RNAI 基因治疗 丙型肝炎 RNAi gene therapy hepatitis C
分类号 R512.63 [医药卫生—内科学]
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参考文献20

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二级参考文献12

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国际病理科学与临床杂志
2009年 第4期

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