摘要
目的:观察知柏地黄丸对三苯氧胺(TAM)治疗乳腺癌患者所产生毒副作用的治疗效果。方法:将64例符合入选标准的乳腺癌患者,随机分为治疗组和对照组。治疗组口服给予三苯氧胺10mg,每日2次;知柏地黄丸8丸,每日3次。对照组仅予三苯氧胺10mg,每日2次口服。治疗两个月后评价疗效,比较两组患者kupperman症状积分、激素水平以及药物不良反应等观察指标。结果:治疗组kupperman症状积分治疗前后差值与对照组比较有显著性差异(P<0.01);治疗组疗效明显优于对照组,有显著性差异(P<0.01)。临床观察发现,加用知柏地黄丸治疗对乳腺癌患者雌激素水平无明显影响,不影响三苯氧胺疗效。结论:应用知柏地黄丸配合三苯氧胺治疗乳腺癌,能够改善潮热汗出、失眠、疲乏及情绪异常等毒副作用,提高生活质量,无明显毒副反应。
Objects： To observe the therapeutic effect of Zhibai Dihuang Wan decrease the TAM （tamoxifen） in treating breast cancer patients. Methods： Sixty-four breast cancer patients who accorded with the inclusion criteria were allocated randomly into treatment and control group. The treatment group was given TAM 10mg, twice per day, Zhibai Dihuang Wan, 8 wan per day orally. The control group was given TAM 10mg, twice per day orally. Then, the therapeutic effects were evaluated two months after the administration of treatment. The main endpoints were kuppermann symptom, quantity life, adverse affects, and the level of estrogen. Results： Compared with the control group, the kuppermann symptom rate in treatment group has statistic significance （P〈0.01）; the effect in treatment group was significant than that in the control group （P〈0.01）. Clinical observation has shown that added Zhibai Dihuang Wan in treating breast cancer will not influence estrogen level and the effect of TAM. Conclusions： Using Zhibai Dihuang Wan to treat patients with breast cancer can not only improve such as flush, perspiration, insomnia, fatigue and irritation, these kind of toxic and side effects, but also can improve life quality and without obvious toxic and side effects.
出处
《广西中医药》
2009年第4期6-8,共3页
Guangxi Journal of Traditional Chinese Medicine
基金
广西科学研究与技术开发计划项目(桂科攻0898019)
