摘要
目的探讨缬沙坦对心力衰竭患者血清地高辛浓度的影响。方法将50例心力衰竭患者随机分为缬沙坦治疗组(A组)和对照组(B组),A组25例,B组25例,A组给予口服缬沙坦80mg/d,B组给予口服5-单硝酸酯40mg/d。结果A组和B组治疗前与治疗后1周、2周、3周、4周,测定血清地高辛浓度,A组和B组无显著性差异(P>0.05)。结论缬沙坦80mg/d与地高辛联用治疗心力衰竭患者,血清地高辛浓度未见升高,提示这两种药物短期联用是安全的。
Objective To investigate the effect of valsartan on heart failure patients with serum digoxin concentration. Methods 50 cases of heart failure patients were randomly divided into valsartan treatment group （A group） and control group （B group）, A group of 25 cases, B group 25 cases, A group of oral valsartan 80mg/d, B groups were given oral 5-Mononitrate 40mg/d. Results A group and B group before and after treatment 1 week, 2 weeks, 3 weeks, 4 weeks, serum digoxin concentration is no significant difference （P〉0.05）. Conclusion Valsartan 80mg/d with digoxin in the treatment of patients with heart failure, serum digoxin concentration is not increase, suggesting that these two drugs are combined treatment with short-term is safe.
出处
《当代医学》
2009年第25期146-147,共2页
Contemporary Medicine
