摘要
目的:建立复方丹参滴丸HPLC数字化指纹图谱。方法:采用反相高效液相色谱法,以色谱指纹图谱相对指数Fr为指标优化确定试验条件,用"中药色谱指纹图谱超信息特征数字化评价系统3.0"评价建立其数字化指纹图谱。结果:测定了10批复方丹参滴丸HPLC指纹图谱,以原儿茶醛为参照物峰,确定15个共有指纹峰,获得了判别其质量的重要数字化信息,并以双定性双定量相似度法评价其批间质量稳定性。结论:所建立的数字化指纹图谱能清晰反映复方丹参滴丸真实质量。
AIM： To establish a digitized HPLC fingerprint of Compound Danshen Dropping PilLs （CDDP）. METHODS： The RP-HPLC condition was optimized by the chromatographic fingerprint relative index （Fr）. The chromatographic fingerprints were characteristically digitized and evaluated by the software of the digitized evaluation system of Traditional Chinese Medicine （TCM） with the super information characteristics. RESULTS： 15 copossessing peaks were selected as the fingerprint peaks of CDDP by taking protocatechualdehyde peak as the referential peak to establish the digitized fingerprint and the important digitized information for its quality control was obtained. The stabilities among different lots of samples were evaluated by the dual qualitative and dual quantitative similarity method. CONCLUSION： The fingerprints can perfectly reflect the authentical quality of CDDP.
出处
《中成药》
CAS
CSCD
北大核心
2009年第8期1152-1155,共4页
Chinese Traditional Patent Medicine
基金
国家自然科学基金重大研究计划课题(90612002)
关键词
复方丹参滴丸
HPLC
数字化指纹图谱
色谱指纹图谱相对指数Fr
双定性双定量相似度法
Compound Danshen Dropping Pills （CDDP）
HPLC
digitized fingerprint
the CFP relative index（Fr）
dual qualitative and dual quantitative similarity method
