摘要
目的缓解妊娠期瘙痒症状,恢复肝功能,降低血胆汁酸浓度,降低胎儿宫内窘迫、围生儿患病率、死亡率和产后出血。方法妊娠期肝内胆汁淤积综合征(ICP)孕产妇136例,其中76例采用丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗(观察组),60例采用口服中药茵陈汤及能量合剂治疗(对照组),分析两组患者的临床诊断、治疗、孕期监护等资料,观察丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗ICP的疗效。结果观察组治疗后瘙痒评分及各项实验室指标明显低于治疗前(P<0.05),与对照组治疗后比较差异有显著性意义(P<0.05),观察组新生儿窒息、早产、胎儿宫内窘迫及产后出血率较对照组低(P<0.05),两组间剖宫产率比较,差异无显著性意义(P>0.05)。结论丁二磺酸腺苷蛋氨酸联合熊去氧胆酸较传统治疗更能改善ICP患者皮肤瘙痒症状及围产儿结局,疗效好,对母婴无副作用,是治疗ICP的有效药物。
Objective To relieve the pruritus, restore liver function, decrease the concentration of bile acid in blood, decrease the probability of intrauterine predicament, morbidity rate of perinatal infant, death rate and postpartum hemorrhage. Methods Seventy-six of 136 cases of pregnant and lying-in women with ICP were allocated into the study group and treated with transmetil and ursodesoxycholic acid. The control group （ n ： 60） were treated with herba artemisiae capillaries soup and energy mixture. Clinical data of diagnosis, treatment, gestational period intensive care and effect of all the ICP patients in the two groups were analyzed. Results After the treatment, the pruritus grade and laboratory parameters of the study group were obviously lower than before（ P 〈 0.05 ）. There were significant differences between the two groups （ P 〈 0. 05 ） and the study group had a lower rate of asphyxia neonatorum, premature labor, intrauterine asphyxia and postpartum hemorrhage than the control group （P 〈 0. 05 I. There were no significant difference for ratio of cesarean section in the two groups （P 〉 0. 05 ）. Conclusions Combination therapy of transmetil with ursodesoxycholic acid could improve the pruritus symptom of intra-hepatic cholestasis patients and the outcome of neonatal infant. It appeared to be an effective agent to treat ICP without any side effects and is better than Chinese medicine and traditional treatment.
出处
《实用医院临床杂志》
2009年第5期110-112,共3页
Practical Journal of Clinical Medicine
