摘要
目的:探讨卡维地洛对慢性心力衰竭(CHF)患者室性心律失常(VA)和心率变异性(HRV)的影响。方法:将97例CHF患者随机分为治疗组49例和对照组48例,治疗组在常规治疗的基础上加用卡维地洛,初始剂量2.5 mg日2次,每2周增加1次剂量,直至20 mg日2次或最大耐受量为止。用动态心电图分析治疗前后心率、VA和HRV变化,并用超声心动图测定患者治疗前后的心功能。结果:治疗组用卡维地洛治疗6个月后,心率下降、VA减少、心率变异性参数改善(P<0.01);心功能增加亦非常显著(P<0.01)。结论:卡维地洛治疗CHF患者,可降低VA的发生,改善HRV和心功能,从而改善预后。
Objective：To investigate the effect of earvediol on ventrictflar arrhythmias and heart rate variabihty in the patients with eongestive heart failure. Methods ：Seventy-nine congestive heart failure patients under conventional therapy were randomly divided into earvediol group （49 eases）and control group （48 cases）.Carvediol was added on basic therapy in 49 patients from initial dosage（2.5 nag B,i. d）,onee adding dosage in an interval of two weeks till target dosage of 20 mg B.i.d or maximal tolerance dosage. Before and after treatment in two groups, the changes of ventrieular arrhythmias, heart rate variability, left ventricle function and volume were observed. Results： After 6 months treatment, compared with control group ,the numbers of ventricular arrhythmias in earvediol group were decreased significantly （P〈0.01） and the index of heart rate variability improved, the standard deviation of normal to normal intervals（SDNN）and the high frequency（HF）increased（P〈0.01）,bat LF/HFdecreased（P〈0.05）. Conclusion：Carvediol can reduce malignant ventricular arrhythmias and improve heart rate variability in the patients with congestive heart failure.
出处
《现代医药卫生》
2009年第18期2752-2754,共3页
Journal of Modern Medicine & Health
关键词
心力衰竭
卡维地洛
室性心律失常
心率变异性
Congestive heart failure
Carvediol
Ventricular arrhythmias
Heart rate variability
