摘要
目的分析2型糖尿病并发肺结核(T2DM-PTB)患者血浆中干扰素-γ(IFN-γ)和白介素-4(IL-4)的分布及其影响因素。方法研究对象分为4组:2型糖尿病并发肺结核组(并发组)、肺结核(PTB)组、2型糖尿病(T2DM)组和健康对照组(Hco组),每组40例。采用酶联免疫吸附(ELISA)法测定各组血浆中IFN-γ和IL-4水平,并采用多元线性回归模型分析影响2者分布的相关因素。结果IFN-γ浓度表现为并发组>TB组>T2DM组>Hco组,组间差异有统计学意义,IL-4在4组间未见差异;血糖控制差、未治疗糖尿病、患糖尿病后减重多、肺部空洞同血浆IFN-γ存在正关联,糖尿病微血管并发症、调查时体质指数与其存在负关联。结论T2DM-PTB患者血浆中Thl/Th2应答有所上调,此上调与血糖控制差、TB病理损伤有关,但2者间孰因孰果尚待研究。
Objective To evaluate the distribution and correlated factors of Interferon-γ（IFN-γ） and Intedeukin-4（IL-4） in the plasma of pulmonary tuberculosis complicated with type 2 diabetes（T2DM-PTB）. Methods The level of IFN-γand IL-4 in plasma were measured with ELISA and compared for four groups： T2DM- PTB group, PTB group, T2DM group and healthy control （Hco） group. Results IFN-γ showed significantly increase by the pattern of T2DM-PTB 〉 PTB 〉 T2DM 〉 Hco, and differences had statistical significance. There was no significant difference of IL-4 level among four groups. Poor glucose control, untreated for DM, weight loss caused by DM, and lung cavity correlated with IFN-3t positively, while microvascular complications of DM and BMI had negative correlation with it. Conclusions T2DM-PTB patients showed up-regulation of Th1/Th2 respond in plasma which might be related to poor glucose control and PTB pathological damage, but further study is needed on the causality of this phenomenon.
出处
《预防医学情报杂志》
CAS
2009年第8期597-599,共3页
Journal of Preventive Medicine Information
基金
国家自然科学基金(30371248)
关键词
结核
肺
糖尿病
2型
血浆
干扰素-Γ
白细胞介素4
Tuberculosis, pulmonary
Diabetes mellitus, Type 2
Plasma
Interferon-γ
Interleukin-4
