摘要
目的:探讨症状性子宫肌瘤患者子宫内膜中tPA、PAI的表达。方法:子宫肌瘤患者子宫内膜标本70例,根据临床有无异常子宫出血的症状分为两组,A组(症状性子宫肌瘤)45例,其中增生期15例,分泌期13例,单纯增生过长10例,复杂增生过长7例;B组(无症状性子宫肌瘤)25例,其中增生期12例,分泌期13例。对照组分为C组和D组,C组:正常子宫内膜28例,其中增生期15例,分泌期13例;D组:功能失调性子宫出血30例,其中增生期11例,分泌期8例,单纯增生过长8例,复杂增生过长3例。采用免疫组化法检测各组子宫内膜中的tPA、PAI表达水平。结果:A组tPA的表达水平与B组和C组比较,均明显升高(P<0.001,P<0.001),但PAI水平明显降低(P<0.001,P<0.001);A组与D组子宫内膜tPA、PAI的表达比较,均无统计学差异(P>0.05);B组与C组子宫内膜tPA、PAI表达水平比较,均无统计学差异(P>0.05);D组与B组和C组比较,tPA表达水平升高,有统计学差异(P<0.001,P<0.001),而PAI水平降低(P<0.001,P<0.001)。结论:症状性子宫肌瘤患者子宫内膜中存在tPA、PAI的表达异常,且这种异常变化趋势与功能性子宫出血的内膜变化趋势一致。tPA、PAI的表达异常是临床上症状性子宫肌瘤患者发生异常子宫出血的原因。
Objective： To explore expression levels of tissue plasminogen activator （tPA） , plasminogen activator inhibitor （PAl） in the endometrium of patients with symptomatic uterine leiomyomas. Methods： 70 cases with uterine leiomyomas were divided into two groups according to abnormal metrorrhagia or not： group A （45 cases with symptomatic uterine leiomyomas） included 15 cases of prolifera- tive phase endometrium, 13 cases of secretory phase endometrium, 10 cases of simple hyperplasia and 7 cases of complex hyperplasia; group B （25 cases with asymptomatie uterine leiomyomas） included 12 cases of proliferative phase endometrium and 13 cases of secretory phase endometrium. 28 cases with healthy endometrium were selected as grodp C, including 15 cases of proliferative phase endometrium and 13 cases of secretory phase endometrium. 30 cases with dysfunctional uterine bleeding were selected as group D, including 11 cases of proliferative phase endometrium, 8 cases of secretory phase endometrium, 8 cases of simple hyperplasia and 3 cases of complex hyperplasia. The levels of tPA, PAl in four groups were detected by immunohistochemistry. Results ： The level of tPA in group A was significantly higher than those in group B and group C （ P 〈 0. 001, P 〈 0. 001 ）, but the level of PAl reversed （ P 〈 0. 001, P 〈 0. 001 ） ; there was no diffelence in the levels of tPA and PAl between group A and group D （ P 〉 0. 05 ） ; there was no difference in the levels of tPA and PAl between group B and group C （ P 〉 0. 05 ） ; the level of tPA in group D was significantly higher than those in group B and group C （ P 〈 0. 001, P 〈0.001）, but the level of PAI reversed （P〈0.001, P〈0.001 ） . Conclusion ： Abnormal expression levels of tPA and PAI can be found in endometrium of patients with symptomatic uterine leiomyomas, and the change tendency is in conformity with endometrium change of dysfunctional uterine bleeding. The abnormal expression levels of tPA and PAI in endometrium ar
出处
《中国妇幼保健》
CAS
北大核心
2009年第24期3415-3417,共3页
Maternal and Child Health Care of China
