摘要
[目的]探讨饮食总能量、蛋白质、脂肪和碳水化合物摄取与结直肠癌发病风险的关系。[方法]在江苏省进行的一项病例对照研究,用包括83种食物摄取频度和摄取量的问卷表,调查了342例结直肠癌患者和393例健康对照的饮食状况,计算各类饮食营养素的平均每日摄取量,采用三分位法分析营养素摄取与结直肠癌发病风险的关系,OR值计算采用非条件Logistic回归方法。[结果]结肠癌组脂肪摄取量显著高于对照组;直肠癌组总能量和蛋白质摄取量显著低于对照组;结、直肠癌组的碳水化合物摄取量均显著低于对照组。在调整可疑混杂因素的影响后,总能量和碳水化合物摄取量高显著降低结直肠癌的发病风险,脂肪摄取量高显著增加结直肠癌的发病风险。但在营养素互相调整后,总能量、蛋白质和脂肪摄取对结、直肠癌的发病风险的影响无统计学意义,而增加碳水化合物的摄取可显著降低结、直肠癌的发病风险(结肠癌OR=0.44,95%CI:0.28～0.71;直肠癌OR=0.51,95%CI:0.36～0.74)。[结论]饮食营养素摄取影响结直肠癌的发病风险,增加碳水化合物摄取可预防结直肠癌的发生。
[Purpose ] To investigate the relationship of dietary intake of energy, protein, fat, and carbohydrate with risk of colorectal cancer. [Methods ] A case-control study including 342 cases with colorectal cancer and 393 health controls were conducted in Jiangsu province, China. Dietary intake of nutritive factors was assessed using an 83-item food frequency questionnaire. Tertile distributions of dietary intake of nutritive factors among controls were used to categorize the variables. Odds ratio （OR） was estimated with an unconditional logistic model. [Results] Consumption of fat in colorectal cancer cases was significantly higher than that in controls. Consumptions of energy and protein in rectal cancer cases were significantly lower than those in controls. Whereas consumptions of carbohydrate in cases of colon and rectal cancers were significantly lower than those in controls. After adjusting for sex, age, BMI, occupation, work intensity, income, status of smoking and drinking, the consumers of highest tertile of energy and carbohydrate had a decreased OR and the consumers of highest tertile of fat had an increased OR for colorectal cancer. After further adjusting for nutritive factors each other, the actions of energy, protein and fat to risk of colorectal cancer were not significant, but OR for colorectal cancer decreased significantly with increasing carbohydrate consumption （0.44, 95%CI： 0.28- 0.71 for colon cancer and 0.51, 95%CI： 0.36-0.74 for rectal cancer）. [Conclusion] Dietary intake of nutritive factors are related with risk of colorectal cancer. Carbohydrate intake appears to protect against colorectal cancer.
出处
《中国肿瘤》
CAS
2009年第8期620-623,共4页
China Cancer
基金
日本文科省国际学术研究癌症特别研究经费(08042015)
国家自然科学基金国际重大合作项目(30320140461)
江苏省卫生厅预防医学科研项目(Y200738)
关键词
结直肠肿瘤
饮食
营养素
病例对照研究
江苏
colorectal neoplasms
dietary
nutritive factors
case control study
Jiangsu
