摘要
目的:研究六月青(LYQ)含药血清对HepG2.2.15细胞乙型肝炎病毒(HBV)复制的抑制作用。方法:采用血清药理学方法,在HBV的体外细胞培养系统(HepG2.2.15细胞)中观察LYQ抗HBV的作用。结果:LYQ含药血清在HepG2.2.15细胞培养中可有效地抑制HBV DNA的复制,其作用呈显著的浓度-效应和时间-效应关系。结论:LYQ在体外能显著抑制HBV,可能是复方六月雪主要活性成分之一。
OBJECTIVE： To study the anti- HBV activity of Strobilanthes affinis in HepG2.2.15 cells. METHODS： The anti- HBV activity of S.affinis was observed in the in vitro cell culture system of HBV（HepG2.2.15 cells） by serum-pharmacology method. RESULTS： The serum containing S.affinis effectively inhibited the HBV DNA duplication in HepG2.2.15 cell culture, and its inhibitory activity assumed dose - dependent and time - dependent manner. CONCLUSION： S.affinis can significantly inhibit HBV in vitro and it maybe one of the main active components of Compound liuyuexue.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第24期1847-1849,共3页
China Pharmacy
基金
广西教育厅科研项目(200710MS014)
广西大型仪器协作共用网资助项目(601-2008-014)
