摘要
ig阿仑膦酸钠2.5,5和10mg/kg对小鼠的协调运动和自主活动,麻醉猫的呼吸频率、呼吸深度、平均动脉压、心率及心电图无明显影响;iv 5mg/kg对麻醉猫的呼吸、血压、心率及心电图亦无明显影响。iv 10mg/kg对麻醉猫的血压有短暂降低作用,对呼吸、心率及心电图无显著改变。
It was found that alendronate(2.5,5 and 10mg/kg,ig) had no obvious effects on the coordinative motor performance and spontaneous activity in conscious mice, the rate and amplitude of respiration, mean blood pressure, heart rate and ECG in anaesthetized cats.Except for a transient decrease caused by alendronate(10mg/kg,iv) in blood pressure, alendronate(5 or 10mg/kg,iv) also had no significant effects on the respiration, blood pressure, heart rate and ECG in anaesthetized cats.
出处
《中国现代应用药学》
CAS
CSCD
1998年第3期1-3,共3页
Chinese Journal of Modern Applied Pharmacy
