摘要
目的:探讨首发抑郁症患者的糖脂代谢情况。方法:对80例首发抑郁症患者及40名健康对照者先进行简易体脂参数的测量,然后进行糖耐量试验(OGTT),并检测其空腹血浆胰岛素、三酰甘油(TG)、总胆固醇(TC)的浓度。结果:体脂参数、空腹血浆胰岛素的浓度、餐后0、1、3h血糖值,两组间差异均无显著统计学意义(P均>0.05);抑郁症组空腹血糖值(FBS)、餐后2h的血糖值、OGTT血糖曲线下面积(AUC)、TG值明显高于对照组(P<0.01);而高密度脂蛋白(HDL-c)、载脂蛋白A1(ApoA1)值抑郁症组明显低于对照组(P<0.01),TC、低密度脂蛋白胆固醇(LDL-c)和载脂蛋白B(ApoB)值两组间差异均无统计学意义(P均>0.05);两组糖耐量减退(IGT)的发生率差异有统计学意义(P<0.05),抑郁症组IGT发生率较对照组高。结论:首发抑郁症患者存在一定的糖脂代谢异常,临床医师应该对抑郁症患者的血糖、血脂进行随访监测,以便早期发现、治疗糖脂代谢性疾病。
Objective：To study the metabolism of glucose and lipid in patients with first-episode depression. Method：Parameters such as body weight index and lipid were measured in 80 patients with first-episode depression and 40 healthy controls. All the patients and controls were conducted oral glucose tolerance test （OGTT） , and their fasting plasma concentration of insulin, triglyeeride （TG） and cholesterol were measured. Results：There was no significance between the two groups in parameters of body weight index and lipid,fasting plasma level of insulin and postprandial glucose at 0 hour, 1 hour, 3 hour （ all P 〉 0.05 ）. The patients in depression group had statistically higher fasting plasma glucose, postprandial glucose at 2 hour, area under curve （AUC） of OGTT,and triglyceride,and lower high density lipoprotein cholesterol （HDL） and ApoA1 ,respectively, compared with that in healthy group （ P 〈 0.01 ）. There was no significant difference in low density lipoprotein cholesterol （LDL） and ApoB between the two groups. Statistical difference in the incidence of impaired glucose tolerance （IGT） was seen between the two groups,with higher rate in depression group. Conclusion： First-episode depression may have abnormal metabolism in glucose and lipid. Clinicians should monitor the level of plasma glucose and lipid in patients with depression during their follow-up, and thus early detect and treat the metabolism diseases.
出处
《临床精神医学杂志》
2009年第4期241-243,共3页
Journal of Clinical Psychiatry
关键词
首发抑郁症
血糖
血脂
糖耐量
first-episode depression
glucose
lipid
glucose tolerance
