摘要
目的了解高龄老年男性高尿酸血症的发病率及l临床特点，探讨其相关影响因素。方法选择2007年在我院进行常规体检的90岁以上老年男性100例为研究对象，比较不同血尿酸水平人群临床及生化指标，对影响高尿酸水平的诸多因素进行Logistic回归分析。结果90岁以上老年男性血尿酸增高的比例为20％，痛风性关节炎的发生率为1％。尿酸增高组血尿素及肌酐水平分别为（10．98±4．29）mmol／L和（125．2±25．9）μmol／L，均明显高于尿酸正常组[（6．87±1．86）mmol／L和（93．4±19．8）μmol／L]（t=4．460和t=4．279，均为P〈0．05）。并存高血压、高三酰甘油血症、应用利尿剂的比率高于尿酸正常组（X^2=4．762、9．219、4．080，均为P〈0．05）。Logistic回归分析显示，血尿酸与血肌酐相关性最为明显（OR—1．969），其次为空腹血糖（OR一1．310）和血尿素（OR=1．161），与胆固醇（OR=0．802）呈负相关。结论90岁以上老年人高尿酸血症患病率较高，急性痛风性关节炎发病率低；主要危险因素是肾功能下降、高血糖及利尿剂的应用。
Objective To explore the prevalence and clinical features of hyperuricemia and its influencing factors in elderly male people aged 90 years and above. Methods One hundred elderly male people aged 90 years and above who underwent routine health examination in our hospital in 2007 were selected in the study. Serum uric acid level was examined by uriease-peroxidase method, and all patients were divided into hyperuricemia group and control group according to the serum uric acid level. Clinical and biochemical indications were compared between the two groups, and logistic regression was used to analyze the influencing factors of hyperurieemia in elderly people. Results The serumthritis was 1%. The levels of blood urea nitrogen and serum creatinine were higher in hyperuricemia group than in control group [（10. 98±4. 29） mmol/L vs. （6. 87±1. 86）mmol/L, （125.2±25.9） μmol/L vs. （93.4±19.8）μmol/L; both P（0.05）]. The patients in hyperuricemia group had a higher prevalence of hypertension and hypertriglyceridemia, and a higher proportion of diuretic application than patients in control group（P〈0.05）. Logistic regression analysis showed that serum uric acid level had the most remarkable correlation with serum creatinine（OR = 1. 969）, followed by fasting blood glucose （OR=1. 310）and blood urea nitrogen（OR= 1. 161）. There was negative correlation between serum uric acid level and plasma cholesterol level（OR = 0. 802）. Conclusions The prevalence of hyperuricemia is high in elderly people aged 90 years and above, while the incidence of gouty arthritis is low. Renal function impairment, metabolic syndrome and thiazide diuretic are the major factors for hyperuricemia.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2009年第8期665-667,共3页
Chinese Journal of Geriatrics
