摘要
目的观察肝硬化患者血浆氨基末端B型尿钠肽前体、血清一氧化氮和血红蛋白的变化及相关性。方法测定58例肝硬化患者和30例健康对照的血浆氨基末端B型尿钠肽前体、一氧化氮和血红蛋白水平;同时按血红蛋白水平将肝硬化患者分为贫血组和非贫血组。结果肝硬化患者血浆氨基末端B型尿钠肽前体、一氧化氮明显高于健康对照组(P<0.01),血红蛋白水平明显低于健康对照组(P<0.01)。肝硬化患者贫血组血浆氨基末端B型尿钠肽前体明显高于非贫血组(P<0.05);肝硬化患者血浆氨基末端B型尿钠肽前体水平与一氧化氮呈正相关(P<0.05),与血红蛋白呈负相关(P<0.05)。结论肝硬化患者血浆氨基末端B型尿钠肽前体升高可能提示心功能不全,一氧化氮水平的升高和血红蛋白水平的降低可能参与了肝硬化患者心功能不全的病理生理过程。
Objective To investigate the relationship among level of plasma n-terminal pro brain natriuretic peptide（NT- pro-BNP） ,nitirc oxide（NO） and hemoglobin （Hb） in patients with cirrhosis. Methods The plasma NT-pro-BNP, serum NO and Hb levels were determined in 58 patients with cirrhosis and 30 healthy controls. Meanwhile 58 patients with cirrhosis were designed in the anemia group and non-anemia group. Results The levels of plasma NT-pro-BNP and serum NO were significantly elevated and the leves of Hb was decreased in patients with cirrhosis compared with the control. The levels of plasma NT-pro- BNP in the anemia group was higher than in the non-anemia group. There were positive correlation between NT-pro-BNP and NO; negative correlation between NT-pro-BNP and Hb. Conclusion The plasma NT-pro-BNP levels in cirrhosis are significantly ele- vated, which is related to cardiac dysfunction in patients with cirrhosis. Increase of NO and decrease of Hb may associate with cardiac dysfunction on patho-physiology in patients with cirrhosis.
出处
《临床消化病杂志》
2009年第4期224-225,共2页
Chinese Journal of Clinical Gastroenterology
关键词
肝硬化
氨基末端B型尿钠肽前体
一氧化氮
血红蛋白
Cirrhosis
N-terminal pro bran natriuretic peptide（NT-pro-BNP）
Nitric oxide（NO）
Hemoglobin
