摘要
目的了解Alzheimer病(AD)与老年精神分裂症患者(SS)在感觉性诱发电位检查中的异同。方法共收集39例AD患者、34例SS患者及40名正常老年人(NC)对照。应用丹麦仪器以及光和声刺激,完成视觉诱发电位(VEP)和听觉诱发电位(AEP)检查。结果发现AD组波形变异大,VEP的N2、P3以及AEP的P1、N1、P2、N2、P3波潜伏期明显延迟,VEP主波P2平均波幅较SS组和NC组分别降低32%和57%。AEP主波P2平均波幅较SS组和NC组分别降低36%和70%。SS组VEP和AEP的N2、P3均比NC组明显延迟。SS组VEP和AEP/P2波平均波幅比NC组降低分别为16%和20%。结论VEP和AEP可作为AD患者和SS患者鉴别诊断的辅助手段。
Objective To investigate the differences of visual evoked potentials(VEP) and auditory evoked potentials(AEP) between patients with Alzheimer′s disease and schizophrenics. Methods Both VEP and AEP were elicited from 39 patients with Alzheimer′s disease, 34 aged schizophrenics and 40 normally agematched subjects. Results The variability of waveforms of both VEP and AEP became increased within the AD group. The AD patients presented significantly delayed latencies (N2 and P3 of VEP; P1, N1, P2, N2 and P3 of AEP) as compared to the normal controls. The P2 amplitude of VEP of AD patients was 32% lower than that of schizophrenics and 57% lower than that of the controls. The P2 amplitude of AEP of AD patients was 36% lower than that of schizophrenics and 70% lower than that of the controls. Compared with the normal controls, the schizophrenics showed reduced VEPP2 latency, prolonged N2 and P3 latencies of both VEP and AEP. The P2 amplitudes of VEP and AEP of schizophrenics were decreased by 16% and 20% respectively as compared to the normal controls. Conclusion The variations of VEP and AEP are a referential tool for diagnosing Alzheimer′s disease and schizophrenia.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1998年第9期674-676,共3页
National Medical Journal of China
基金
上海市医学领先专业重点学科资助
关键词
早老性痴呆
精神分裂症
听觉诱发电位
Alzheimer′s disease Schizophrenia Evoked potentials, auditory