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阿尔茨海默病与老年精神分裂症患者的诱发电位比较 被引量:3

Brain evoked potentials in patients with Alzheimer′s disease and schizophrenia: a comparative study
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摘要 目的了解Alzheimer病(AD)与老年精神分裂症患者(SS)在感觉性诱发电位检查中的异同。方法共收集39例AD患者、34例SS患者及40名正常老年人(NC)对照。应用丹麦仪器以及光和声刺激,完成视觉诱发电位(VEP)和听觉诱发电位(AEP)检查。结果发现AD组波形变异大,VEP的N2、P3以及AEP的P1、N1、P2、N2、P3波潜伏期明显延迟,VEP主波P2平均波幅较SS组和NC组分别降低32%和57%。AEP主波P2平均波幅较SS组和NC组分别降低36%和70%。SS组VEP和AEP的N2、P3均比NC组明显延迟。SS组VEP和AEP/P2波平均波幅比NC组降低分别为16%和20%。结论VEP和AEP可作为AD患者和SS患者鉴别诊断的辅助手段。 Objective To investigate the differences of visual evoked potentials(VEP) and auditory evoked potentials(AEP) between patients with Alzheimer′s disease and schizophrenics. Methods Both VEP and AEP were elicited from 39 patients with Alzheimer′s disease, 34 aged schizophrenics and 40 normally agematched subjects. Results The variability of waveforms of both VEP and AEP became increased within the AD group. The AD patients presented significantly delayed latencies (N2 and P3 of VEP; P1, N1, P2, N2 and P3 of AEP) as compared to the normal controls. The P2 amplitude of VEP of AD patients was 32% lower than that of schizophrenics and 57% lower than that of the controls. The P2 amplitude of AEP of AD patients was 36% lower than that of schizophrenics and 70% lower than that of the controls. Compared with the normal controls, the schizophrenics showed reduced VEPP2 latency, prolonged N2 and P3 latencies of both VEP and AEP. The P2 amplitudes of VEP and AEP of schizophrenics were decreased by 16% and 20% respectively as compared to the normal controls. Conclusion The variations of VEP and AEP are a referential tool for diagnosing Alzheimer′s disease and schizophrenia.
出处 《中华医学杂志》 CAS CSCD 北大核心 1998年第9期674-676,共3页 National Medical Journal of China
基金 上海市医学领先专业重点学科资助
关键词 早老性痴呆 精神分裂症 听觉诱发电位 Alzheimer′s disease Schizophrenia Evoked potentials, auditory
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参考文献3

  • 1张明岛,脑诱发电位学(第2版),1997年,97页 被引量:1
  • 2陈兴时,国外医学.精神病学分册,1994年,4卷,78页 被引量:1
  • 3杨玲玲,器质性精神病学,1993年,78页 被引量:1

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