摘要
阿托品对兔局部脑缺血Ｃａ２＋积累和细胞水肿的作用吕爱刚胡香杰贾丹辉张贵卿可君（河南医科大学药理学教研室，郑州４５００５２）阿托品（ａｔｒｏｐｉｎｅ，Ａｔｒ）为一典型的Ｍ受体阻断剂，近年研究表明它可以选择性对抗ＫＣｌ和ＣａＣｌ２对兔基底动脉收缩作用，其...
Experimental brain ischemia model was prepared by middle cerebral artery occlusion(MCAO) operation in rabbits. Effects of atropine(Atr) on Ca^2+, Na^+, K^+,H_2O contents of ischemic area were examined 5 h after MCAO. Atr 0.7 mg·kg1·h1, iv, 5 min after MCAO for 5 h significantly reduced Ca2+ accumulation, Na+ level and H2O content in ischemic area (P<0.01). Atr 0.35 mg·kg1·h1 iv for 5 h after MCAO also reduced Na+ contents in ischemic area (P<0.05). The results suggest that Atr protect regional brain ischemia infarct and edema in rabbits.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1998年第3期237-238,共2页
Chinese Journal of Pharmacology and Toxicology
关键词
脑缺血
药物疗法
阿托品
钙
钠
脑水肿
cerebral ischemia
atropine
calcium
sodium
potassium
brain edema
