摘要
目的探讨多西紫杉醇周方案和三周方案治疗老年人非小细胞肺癌的临床疗效与不良反应。方法回顾性分析安徽医科大学第一附属医院2005年10月至2008年12月收治的73例用多西紫杉醇治疗的老年晚期非小细胞肺癌患者的临床资料。结果周方案治疗43例,有效率37.2%(16/43),三周方案治疗30例,有效率33.3%(12/30),不良反应主要有恶心呕吐、疲劳、中性粒细胞减少。结论多西紫杉醇周方案治疗老年人非小细胞肺癌疗效较好,不良反应较三周方案轻,患者易耐受。
Objective To evaluate the efficacy and toxicity of docetaxel administered weekly or 3-weekly to elderly patients with advanced non-smal cell lung cancer （NSCLC）. Methods The clinical data of 73 elderly patients with advanced non -smal cell lung cancer admitted from October 2005 to December 2008 to the First Affiliated Hospital of Anhui Medical University were analyzed retrospectively. Results The overall response rate （RR） were 37.2% and 33.3% for the patients treated with weekly or 3-weekly docetaxel regimen respectively. The major side effects were nausea and vomiting, fatigue, neutropenia. Conclusion weekly administration of docetaxel at a dose of 25 mg/m^2 is effective and well tolerable for elderly patients with advanced non-smal cell lung cancer.
出处
《安徽医学》
2009年第8期905-907,共3页
Anhui Medical Journal
关键词
多西紫杉醇
老年人
肺癌
Docetaxel
Elderly patients
Lung cancer
