摘要
胰岛素抵抗、腹型肥胖、脂代谢紊乱、低度慢性炎症和高雄激素是多囊卵巢综合征(PCOS)的主要心血管危险因素,而其他因素如同型半胱氨酸、氧化应激、血栓形成等也可能增加心血管危险。而且,代谢综合征、2型糖尿病、高血压和阻塞性睡眠呼吸暂停等疾病在PCOS人群中更为常见,同样提示PCOS和心血管疾病间可能存在某种关系。然而,目前并无任何流行病学资料显示,PCOS人群比正常同龄人心血管疾病的发病率和死亡率更高。考虑到PCOS中高发的心血管危险因素,仍需对其远期风险给予重视并给予早期干预。
Insulin resistance, abdominal obesity, dyslipidemia, low-grade chronic inflammation and hyperandrogenism are thought to be the main cardiovascular risk factors in polycystic ovary syndrome （PCOS）. Moreover, other factors, such as homocysteine, oxidative stress and thrombosis, probably contribute to their cardio- vascular risk profile. PCOS is also associated with increased risk of metabolic syndrome, type 2 diabetes, hyperten- sion and obstructive sleep apnea, which also suggest some possible link between PCOS and cardiovascular disease （CVD）. There is no epidemiologicat evidence, however, showing that PCOS did not exhibit elevated morbility and mortality of CVD. Taking in consideration of the high risk of PCOS to develop future CVD, long term goals of therapy should focus on its prevention.
出处
《国际妇产科学杂志》
CAS
2009年第4期303-306,314,共5页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(30672228)
关键词
多囊卵巢综合征
心血管疾病
胰岛素抵抗
肥胖
Polycystic ovary syndrome
Cardiovascular disease
Insulin resistance
Obesity
