摘要
传统的标准剂量化疗或大剂量化疗后行自体干细胞移植对多发性骨髓瘤有一定的缓解作用,但存在复发的可能性,因而维持治疗则有助于延长缓解期。维持治疗包括使用烷化剂,干扰素,糖皮质激素,沙利度胺等。各种维持治疗手段有其一定的优势及副作用。真正有效的维持治疗不仅要将疾病的危害最小化,还要延长无病生存期,总生存期及无进展生存期。本文对目前多发性骨髓的的维持治疗方法及潜在的可能的治疗手段做一总结。
Chemotherapy with traditional standard dose or autologous stem cell transplantation（ASCT） after chemotherapy with high dose have some remission effect for multiple myeloma, but relapse still exists. The maintenance treatment would prolonged the remission stage. These treatments included the use of alkylating agent, interferon, corticostefolds, thalidomide and so on. Every maintenance treatment has some advantages and some side effects. The truly effective maintenance treatment would not only minimize the harm of the disease, but also would prolong the overall survival, progression-free survival and the event-flee survival. This article summarizes the current progress in the maintenance treatments for multiple myeloma.
出处
《中国实验血液学杂志》
CAS
CSCD
2009年第4期1111-1117,共7页
Journal of Experimental Hematology
关键词
多发性骨髓瘤
维持治疗
烷化剂
干扰素
糖皮质激素
沙利度胺
multiple myeloma
maintenance treatment
alkylating agent
interferon
corticosteroid
thalidomide
