摘要
环氧合酶-2(COX-2)在Barrett化生-异型增生-腺癌序列中表达增高,可能是参与食管腺癌(EAC)癌变过程的重要因素。多数研究认为COX-2表达上调主要作用于癌变的早期阶段,并可能与酸和胆汁反流及其相关慢性炎症反应有关。COX-2 CA单倍型以及-765C、-1195A、8473 C等位基因可能是EAC易感性的遗传标记。COX-2表达水平可能作为EAC预后评估或预测放化疗敏感性的指标。COX-2抑制剂能否成为EAC化学预防的有效手段尚存在争议。
Expression of cyclooxygenase-2 （COX-2） is up-regulated in Barrett metaplasia-dysplasia-adenocarcinoma sequence, which implies that COX-2 may play an important role in the development of esophageal adenocarcinoma （EAC）. Most studies suggested that COX-2 overexpression mainly affected the early stage of esophageal carcinogenesis, and might be related to the acid/bile reflux and reflux-related chronic inflammation. COX-2 CA haplotype as well as the -765C, -1195A and 8473 C alleles are potential genetic markers for EAC susceptibility. Expression level of COX-2 might be a useful prognostic factor for EAC and the outcome of chemoradiotherapy. However, whether COX-2 inhibitor could be used as an effective chemopreventive measure for EAC is still under debate.
出处
《胃肠病学》
2009年第7期435-438,共4页
Chinese Journal of Gastroenterology
基金
福建省高等学校新世纪优秀人才支持计划项目(NCETFJ-0608)
关键词
环氧合酶2
食管腺癌
BARRETT食管
多态性
单核苷酸
预后
化学预防
Cyclooxygenase-2
Esophageal Adenocarcinoma
Barrett Esophagus
Polymorphism, Single Nucleotide
Prognosis
Chemoprevention
