摘要
目的探讨血压变化对老龄自发性高血压大鼠(SHR)腹侧前列腺增殖的影响。方法SHR给药组在出生1个月后即开始按每天100mg/kg给予喂食卡托普利,并设SHR对照组和正常血压对照组(WKY),每组各5只。间接测量尾动脉收缩压(SBP)。分别在6月龄时、12月龄时处死动物,计算腹侧前列腺重量月增长率和前列腺指数,常规病理检查。结果SHR对照组SBP随月龄增加而上升,在SHR给药组,SBP经大剂量卡托普利治疗后得以控制,但仍高于WKY组。1月龄时,SHR和WKY腹侧前列腺重量平均值分别为186.2mg和130.0mg,6月龄时SHR给药组、SHR对照组及WKY组前列腺重量月增长率(mg/月)分别为25.63±3.59、42.76±14.4和48.26±4.5,12月龄时分别为16.53±1.43、23.32±2.15和28.61±3.99,6月龄或12月龄时SHR给药组前列腺重量月增长率低于同龄SHR对照组及WKY组(P<0.05)。6月龄时SHR给药组、SHR对照组及WKY组前列腺指数(mg/g)分别为1.01±0.09、1.12±0.14和0.93±0.07,12月龄时分别为0.95±0.06、1.11±0.05和0.96±0.09;12月龄的老年SHR给药组的指数明显低于同龄SHR对照组(P<0.05),与同龄WKY组接近(P>0.05);而SHR对照组指数在成年或老年期均高于WKY组(P<0.05)。结论高血压促进SHR BPH的发生发展,早期给予大剂量卡托普利控制血压可延缓SHR发生BPH的进程。
Objective To evaluate the effect of blood pressure on ventral prostate proliferation in aging spontaneously hypertensive rats （SHR）. Methods In the SHRs treatment group, one-month-old rats were treated with captopril （100mg/kg × d^-1）, and age and weight matched untreated SHR and normotensive Wistar Kyoto（WKY） rats served as controls. There were 5 rats in each group. After measurement of systolic blood pressure （SBP） and body weight, all rats were killed at 6 months or 12 months old. The monthly growth rate of prostate weight and prostate index were calculated. Conventional pathological analysis was performed. Results SBP increased with age in SHR control group. SBP of SHR treatment group with high-dose captopril treatment was controlled, but it was still higher than that of the WKY group. The monthly growth rate of rat prostate weight （mg/month） at 6-month-old in SHR treatment group, SHR control group and WKY group was 25.63±3.59, 42.76±14.4 and 48.26±4.5 respectively, at 12 months was16.53±1.43, 23.32±2.15, 28.61±3.99 respectively. The monthly growth rate of rats at 6 or 12-month-old in SHR treatment group was lower than that of the SHR control group and WKY group （P 〈0.05）. The prostate index（mg/g）of rats at 6-month-old in SHR treatment group, SHR control group and WKY group was 1.01±0.09, 1.12±0.14 and 0.93±0.07 respectively, at 12 months was 0.95±0.06, 1.11±0.05, 0.96±0.09 respectively. The prostate index of rats at 12-month-old in SHR treatment group was significantly lower than that of the SHR control group （P 〈0.05） and was similar with that of the WKY group （P〉 0.05）, while the prostate index of the SHR control group in adult or old age were all higher than that of WKY group （P 〈0.05）. Conclusion High blood pressure might promote BPH development in SHR rats, and the control of blood pressure by high-dose captopril might delay the development of BPH in SHR.
出处
《中国男科学杂志》
CAS
CSCD
2009年第7期27-29,32,共4页
Chinese Journal of Andrology
关键词
血压
大鼠
近交SHR
前列腺增生
blood pressure
rats, inbred SHR
prostatic hyperplasia
