摘要
目的:了解骨促结缔组织增生性纤维瘤的临床病理。方法:收集骨促结缔组织增生性纤维瘤1例和6例腹壁外韧带样纤维瘤病的临床资料。手术切除组织HE染色光镜观察。涂胶切片做Vimentin,Desmin,NF,S100蛋白的单克隆标记。结果:骨促结缔组织增生性纤维瘤的组织学改变和免疫组织化学标记与腹壁外韧带样纤维瘤病相似,临床症状和影像学改变与骨样骨瘤相似。结论:骨促结缔组织增生性纤维瘤易发生于青年男性,病理才能将其确诊,有复发的可能。
Objective： To investigate the clinicopathological features of desmoplastic fibroma of bone. Methods： By means of histological, and immunohistochemical studies, the clinical and pathological features of one case of desmoplastic fibroma of bone was analyzed and comparing with 6 cases of soft tissue desmoid type fibromatosis. Results： Patient of desmoplastic fibroma of bone was a young man. The tumor was located at the tibia. Microscopic sections showed a uniform appearance of long, slender,spindle -shaped fibroblasts arranged in bands and faxcicles and surrounded by large amounts of cllagen. Local recurrence following excision occurred in two cases of soft tissue desmoid type fibromatosis. In both desmoplastic fibroma of bone and soft tissue desmoid type fibromatosis immunohistochemical expression of vimentin was positive, and S100 protein ,desmin and NF were negative. Conclusion： Desmoplastic fibro- ma of bone may be recurred. The diagnosis was based on histological observation and immunohistochemical staining.
出处
《现代肿瘤医学》
CAS
2009年第8期1549-1551,共3页
Journal of Modern Oncology
