摘要
目的:探讨胃原发性恶性淋巴瘤黏膜活检病例的临床病理诊断特点。方法:内窥镜胃黏膜活检标本和切除标本经常规石蜡包埋切片、染色和免疫组化染色后光镜下观察。结果:31例活检组织中均呈现不同程度的异型淋巴细胞弥漫浸润,腺体数量减少或完全消失;12例出现淋巴上皮病变,7例出现可疑淋巴上皮病变;13例伴有炎症渗出坏死;8例组织挤压损伤。结论:充分、准确的活检对胃淋巴瘤的确诊具有重要意义;异型淋巴细胞弥漫浸润是活检诊断的主要特征,活检组织中可能不出现淋巴上皮病变;免疫组化染色和分子生物学技术可以提高诊断的准确率;内镜医师和病理医师间的合作是提高诊断率的关键。
Objective：To investigate the pathological characteristics of primary gastric lymphoma in endoscopic biopsied speciments. Methods： All the tissue samples were 10% formalin - fixed, paraffin - embedded, stained and tested with hematoxylin -eosin and SP immunohistochemistry. Results：There were variable atypia, diffuse lymphoid cell infiltration with decrease or disappearance of the gland in the biopsied sample ; The lymphoepithelial lesions were seen in 12 cases and suspect lymphoepithelial lesions in 7 cases;There were inflammatory necrosis and pressing tissues injury in 13 cases. Conclusions：The main diagnostic characteristics of gastric lymphoma are variable atypia, diffuse lymphoid cell infiltration in the biopsied tissues;Lymphoepithelial lesions are not always observed, but other changes are often seen in the biopsied samples.
出处
《现代肿瘤医学》
CAS
2009年第8期1508-1511,共4页
Journal of Modern Oncology
基金
国家教委留学回国人员科研启动基金(教外司留)[1997]436号(BK20087)
南京市留学回国人员科研基金(BK20087)
江苏省卫生厅科技项目基金(BK20087)
关键词
胃肿瘤
淋巴瘤
内窥镜活检
gastric neoplasm
lymphoma
endoscopic biopsy
