摘要
目的:探讨老年结肠癌根治术辅助化疗的临床疗效和安全性。方法:随访107例老年结肠癌根治术后患者,观察接受化疗和未接受化疗患者的3年复发转移率和无病生存情况,同时观察老年患者化疗后不良反应,辅助化疗采用以5-FU为基础药物治疗方案。结果:老年结肠癌根治术后辅助化疗3年复发转移率为28.8%,未化疗组为47.3%,χ2=3.84,P=0.049。化疗与未化疗组患者无病生存时间分别为17、12个月,χ2=4.354,P=0.037。老年患者化疗后毒副反应以白细胞减少(19.23%)、腹泻(11.54%)、恶心、呕吐(11.54%)相对多见,能够耐受。结论:老年结肠癌患者根治术后接受辅助化疗能够获得临床受益,化疗毒副反应没有因年龄因素加大。
OBJECTIVE： To explore the clinical efficacy and safety of adjuvant chemotherapy post resection of colon cancer in elderly patients. METHODS： A total of 107 cases of colon cancer in elderly patients with radical surgery were followed up. The relapse and a metastatic rate during a 3 year period and disease-free survival were investigated in the patients accepting chemotherapy and those who chose not to accept chemotherapy. Concurrently, the side effects of chemotherapy were also observed and documented. 5-fluorouracil-based adjuvant chemotherapy was used in the treatment program. RESULTS： After 3 years, the relapse and metastatic rate in the elderly who accepted chemotherapy was 28.8%, while the rate in the patients who did not accept chemotherapy was 47.3%, Χ^2 = 3.84, P=0. 049. Disease-free survival periods of the two groups were 17 months and 12 months respectively, Χ^2 = 4. 354, P = 0. 037. The side- effects of chemotherapy in the elderly were well tolerated, while incidences of interleukin, dia These rates were rrhea, and nausea and vomiting were relatively common. 19.23%, 11.54% and 11. 54% respectvely. CONCLUSION： The elderly patients with colon cancer can accept and derive clinical benefit from the adjuvant chemotherapy post radical resection and the toxicity of chemotherapy did not increase despite the age factor.
出处
《中华肿瘤防治杂志》
CAS
2009年第12期945-947,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
结肠肿瘤
化学疗法
辅助/方法
治疗结果
colonic neoplasms
chemotherapy, adjuvant/methods
treatment outcome
