摘要
目的探讨左卡尼汀对新生儿窒息后缺氧-缺血性心肌损害的保护作用。方法61例窒息后缺氧-缺血性心肌损害新生儿分为治疗组31例和对照组30例。在其他治疗措施相同的情况下,治疗组加用左卡尼汀干预,疗程14d。观察治疗过程中肌酸激酶同功酶(CK-MB)、心电图及患儿症状体征的变化。结果治疗组在促进心肌酶谱、心电图恢复及改善病儿症状体征等方面优于对照组。结论左卡尼汀对新生儿窒息后缺氧-缺血性心肌损害有保护作用。
Objective To study the protective effects of L-carnitine in newborn with hypoxic ischemic myocardial injury. Methods Sixty-one cases with hypoxic ischemie myocardial injury following neonatal asphyxia were divided into L-carnitine group（L, 31 eases） and control group（C, 30 cases）. The patients in group L received conventioal therapy plus L-carnitine for 14 days and those in group C conventioal therapy alone. The changes of clinical symptoms, physical signs, electrocardiogram （ECG） and creatine kinase muscle brain isozyme（CK-MB） were observed before and after treatment. Results The improvement in the symptoms, physical signs, ECG and CK-MB was remarkably more in group L than that in group C. Conclusion L-carnitine has a protective effect on the myocardium with hypoxic ischemic myocardial injury following neonatal asphyxia.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第8期878-879,共2页
Jiangsu Medical Journal
关键词
左卡尼汀
新生儿窒息
心肌损害
肌酸激酶同功酶
L carnitine
Asphyxia of neonates
Myocardial injury
Creatine kinase muscle brain isozyme（CK-MB）
