摘要
目的分析某院铜绿假单胞菌感染患者耐药情况及发生泛耐药的相关临床危险因素。方法回顾性分析该院2008年1月1日－2009年5月1日间分离的538株铜绿假单胞菌对18种常用抗菌药物的耐药状况，并对其中泛耐药铜绿假单胞菌感染患者（泛耐药组，28例）的住院资料与同期非泛耐药铜绿假单胞菌感染患者（对照组，48例）进行比较。结果538株铜绿假单胞菌对阿米卡星和哌拉西林／他唑巴坦较为敏感，耐药率分别为18．40％和27．70％；而对亚胺培南、美罗培南、头孢他啶及环丙沙星的耐药率较高，分别为69．52％、56．88％、45．91％和56．88％。检出泛耐药铜绿假单胞菌28株，占5．20％。对泛耐药组与对照组患者的分析表明，泛耐药铜绿假单胞菌感染的危险因素有：气管插管、长时间入住重症监护室（ICU）及长期联合应用抗菌药物。结论铜绿假单胞菌对多种抗菌药物耐药率较高，尤其对亚胺培南耐药率增加，应引起临床高度重视。对于入住ICU及应用多种抗菌药物的患者，尤其是应用机械通气者，应警惕泛耐药铜绿假单胞菌感染。
Objective To evaluate drug resistance and risk factors of pan-drug resistance of Pseudomonas aeruginosa （PDRPA） isolated from clinical specimens in a hospital. Methods Five hundred and thirty-eight strains of Pseudomonas aeruginosa （PA） were isolated from a hospital between January lst,2008 and May 1st, 2009, the results of susceptibility test of PA to 18 kinds of antimicrobial agents were analyzed retrospectively. The clinical data of patients with PDRPA infections （PDRPA infection group, 28 cases） were compared with that of patients without PDRPA infections（ control group, 48 cases） during the same hospitalization period. Results Among 538 strains of non-repeated PA, resistance to amikacin and piperacillin/tazobactam was low, which was 18. 40% and 27, 70% respectively; resistance to imipenem, meropenem, ceftazidime and ciprofloxacin was 69. 52%, 56. 88%, 45. 91 % and 56. 88% respectively. 28 （5. 20%） strains was PDRPA. Risk factors for PDRPA infections were tracheal intubation, long time hosptalization in ICU and long-term combination of antimicrobial application. Conclusion Drug-resistant rates of PA to multiple antimicrobial agents are very high, especially resistance to imipenem, which should be paid attention to. Patients hospitalized in ICU and using multiple antimicrobial agents, especially those with mechanical ventilation, should be paid attention to PDRPA infection.
出处
《中国感染控制杂志》
CAS
2009年第4期274-276,共3页
Chinese Journal of Infection Control
关键词
铜绿假单胞菌
抗菌药物
抗药性
微生物
泛耐药菌株
危险因素
Pseudomonas aeruginosa
antimicrobial agents
drug-resistance, microbial
pan-drug resistant strains risk factor
