摘要
人血浆脂蛋白相关磷脂酶A2（1ipoprotein-associated phospholipase A2，Lp-PLA2）由成熟的巨噬细胞和淋巴细胞分泌，主要与低密度脂蛋白结合。近年来的研究表明，Lp-PLA2在动脉粥样硬化形成过程中起着重要作用，其基因多态性与缺血性卒中发生相关，其特异性抑制剂具有抗动脉粥样硬化作用。kp-PLA2可能是缺血性卒中的新型独立危险因素和治疗靶标。
The human plasma lipoprotein-associated phospholipase A2 （Lp-PLA2） is secreted by the mature macrophages and lymphocytes, which predominantly binds to low-density lipoprotein. Studies in recent years have demonstrated that Lp-PLA2 plays an important role in the process of atherogenesis. Its gene polymorphisms are associated with the occurrence of ischemic stroke, and its specific inhibitor has anti-atherogenic effects. Lp-PLA2 may be a novel independent risk factor and a therapeutic target for ischemic stroke.
出处
《国际脑血管病杂志》
北大核心
2009年第6期463-466,共4页
International Journal of Cerebrovascular Diseases
