摘要
目的探讨金橘黄酮的免疫功能。方法环磷酰胺诱导小鼠免疫功能低下,予金橘黄酮,观察小鼠碳粒廓清指数K、吞噬指数a、胸腺和脾脏指数、耳肿胀度、血清溶血值(HC50)等指标的变化。结果与模型对照组相比,金橘黄酮80mg/kg.bw剂量时,小鼠碳粒廓清指数K、吞噬指数a、胸腺和脾脏指数、耳肿胀度有显著提高(P<0.05),血清溶血值(HC50)有极显著提高(P<0.01);金橘黄酮160mg/kg.bw剂量对全部试验参数的影响具有极显著性(P<0.01)。结论金橘黄酮对于免疫低下型小鼠的免疫功能具有一定的恢复作用。
Objective To explore the effects of Fortunella crassifolia flavonoids on immune function of immunodepressed mice. Methods The immunosuppressed mice were induced by cyclophosphamide （CY） and Fortunella crassifolia flavonoid was taken orally. The immunodulatory effects were measured by clearance rate K of charcoal particles, phagocytic index a, thymus and spleen index, ear swelling degree, HC50 value and so on. Results Compared with model group, the clearance rate K of charcoal particles, phagocytic index a, thymus and spleen index and ear swelling degree of 80 mg/kg · bw Fortunella crassifolia flavonoid dose group were significantly improved（P 〈0.05）, and a very significant effect （P 〈0. 01 ） was made to the HC50 value at this dose. While the dose was increased to 160 mg/kg · bw, all of the experimental parameters showed extremely significant improvements （P 〈 0.01 ） . Conclusion Fortunella mrassifolia flavonoid can partly rejuvenate the immune reactivity of the immunosuppressed mice.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第7期1599-1600,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家"十五"科技攻关专题(No.2001BA535C-8)
关键词
金橘
黄酮
免疫功能
Fortunella cargarita
Flavonoids
Immune function
