摘要
目的:探讨卵巢颗粒细胞瘤(GCT)中增殖细胞相关核抗原(Ki67)的表达及意义。方法:采用免疫组化法检测Ki67在37例GCT中的表达,并分析其与临床病理参数的关系。结果:病例组GCT组织中Ki67表达高于对照组(P<0.05);随临床分期升高Ki67表达水平升高(P<0.05);核分裂相高者Ki67增殖指数高于核分裂相低者(P<0.05);复发病例Ki67表达高于原发病例(P<0.05);在成年型GCT中弥漫型Ki67增殖指数高于滤泡型(P<0.05)。结论:GCT中Ki67表达与临床分期、组织学类型有关,检测Ki67表达对GCT的诊断及判断预后可提供理论依据。
Objective：To investigate expression and significance of proliferation cell nuclear antigen（Ki67）in human ovarian granulosa cell tumor. Methods：Ki67 expression in cancer tissue was detected by immunohistochemical method,and correlations between Ki67 expression level and clinical pathological parameters were analyzed. Results：There were significant differences on Ki67 expression level among the cases of Ⅰ,Ⅱ, Ⅲ stage（7.72±2.22,13.07±4.18,16.80±1.71 ,P〈0.05） ; Ki67 expression level in the cases of karyokinesis ≥3/HPF was higher than that in the cases of karyokinesis 〈3/HPF （P〈 0.05） ;Ki67 expression level in recurrent cases was higher than that in primary cases （P〈0.05）;Ki67 expression level in diffuse pattern cases was significantly higher than that in follicular pattern cases （P〈0.05）. Conclusion：Ki67 is related to clinical stages and histological types, and its expression can provide a theoretical basis for diagnosis and prognosis of ovarian granulosa cell tumor.
出处
《山西中医学院学报》
2009年第3期64-66,共3页
Journal of Shanxi College of Traditional Chinese Medicine
关键词
卵巢颗粒细胞瘤
KI67
临床分期
病理参数
ovarian granulosa cell tumors
Ki67
clinical stages
pathological parameter
