摘要
目的探讨曼月乐的临床应用疗效。方法对于健康妇女单纯要求避孕者81例，子宫腺肌症患者要求避孕及治疗者32例，子宫内膜异位症患者保守手术后要求尝试治疗者6例，月经过多的功能性子宫出血（经诊刮病理确诊）患者要求治疗者10例，适时宫内放置曼月乐，定期随访观察避孕效果、月经、痛经程度、子宫腺肌症患者子宫大小、功能性子宫出血患者子宫内膜厚度等变化。结果曼月乐带器妊娠率为0，放置曼月乐12个月后，所有妇女的月经量为放置前的（8±3）％，子宫腺肌症患者血清CA125水平由72±50kU／L下降至31±24kU／L，治疗前后相比，差异有统计学意义（t=2．373，P〈0．05）；功能性子宫出血患者子宫内膜厚度由13．2±5．1mm变薄为5．9±1．9mm，治疗前后相比，差异有统计学意义（t=3．452，P〈0．01）；健康妇女及子宫腺肌症患者的痛经症状完全缓解，子宫内膜异位症患者的痛经有4例完全缓解或明显缓解，2例部分缓解。结论曼月乐在避孕及子宫腺肌症、功能性子宫出血的治疗上均效果显著，对子宫内膜异位症的治疗有一定的疗效。
Objective To observe clinical efficacy and safety of levonorgestrel-releasing intrauterine system （LNG-IUS）. Methods 81 healthy women who only required contraception, 32 women with adenomyosis （AM） who required contraception and treatment, 6 women after conservative operation for endometriosis （EMs） who wanted an attempting treatment and 10 women with dysfunctional uterine bleeding （DUB） presenting menorrhagia （confirmed by diagnostic curettage and pathological examination） required treatment were inserted LNG-IUS into their uterine cavity timely and were regularily followed-up for contraceptive effect, menstruation, dysmenorrhea severity, size of uterine and endometrial thickness. Results The pregnancy rate in women carting LNG-IUS was O. After 12 months treatment of LNG-IUS, the menstrual amounts of all women were reduced significantly to （ 8 ± 3 ） % of that before treatment （ P 〈 0.01 ）. The serum level of CA125 of the patients with AM dropped from 72 ± 50kU/L to 31 ± 24kU/L, and the difference was statistically significant （t = 2. 373 ,P 〈 0.05）. The endometrial thickness of patients with DUB was thinned from 13.2 ± 5. 1mm to 5.9 ± 1.9mm, and the difference was statistically significant （ t = 3. 452, P 〈 0.01 ）. The symptom dysmenorrhea of healthy women and patients with AM was completely remitted, while that of 4 patients with EMs was completely or remarkably remitted, and that of 2 patients with EMs was partly remitted. Conclusion LNG-IUS presents significant contraceptive effect and therapeutic effect for AM and DUB, also, it exerts certain therapeuitc effect for EMs.
出处
《中国妇幼健康研究》
2009年第4期442-445,共4页
Chinese Journal of Woman and Child Health Research
