摘要
目的:评价不同剂量碘化油经肝动脉化疗栓塞(TACE)后兔肝VX2移植瘤转移与坏死的关系.方法:将48只荷瘤兔随机分成3组,每组16只.对照组经肝动脉灌注0.5mL生理盐水;常规剂量组经肝动脉灌注5 mg阿霉素与常规剂量碘化油的混悬液;大剂量组经肝动脉灌注5 mg阿霉素与大剂量碘化油的混悬液.常规剂量组和大剂量组碘化油用量(mL)分别为肿瘤体积(cm3)乘以0.5和1.经股动脉穿刺插管,依分组情况行介入治疗,比较不同处理组肝脏原位移植瘤治疗后2 wk的坏死分级、肝内转移率、肺转移率及转移与坏死分级的关系.结果:与常规剂量组相比,大剂量组肿瘤的坏死分级明显增加(P<0.01),肝内转移、肺转移的转移率明显降低(P<0.05).肿瘤的转移率和肿瘤的坏死分级呈负相关.结论:大剂量碘化油TACE能明显降低兔肝VX2移植瘤肝内转移及肺转移的发生率;其可能通过致移植瘤完全坏死或大部分坏死以降低栓塞后肝内转移及肺转移的发生率.
AIM： To evaluate the relation of metastasis and necrosis of rabbit hepatic VX2 tumor after transcatheter arterial chemoembolization （TACE） of different dose of iodized oil. METHODS：Forty-eight rabbits with implanted hepatic VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high dose iodized oil TACE group. 0.9% saline,5 mg adriamycin combine routine dose iodized oil and 5 mg adriamycin combine high dose iodized oil were perfused respectively via hepatic artery in different groups. The amounts of iodized oil of routine dose iodized oil TACE group and high dose iodized oil TACE group were 0.5 and 1 time of tumor volume respectively. The necrosis area, intrahepatic and lung metastasis of tumor were examined after 2 weeks of TACE procedure. RESULTS：There was more necrosis areas of the high dose iodized oil TACE group compared with the control group and the routine dose iodized oil TACE group （P〈0.05）;In the high dose iodized oil TACE group,there were less intrabcpatic and lune metastasis compared with the routine dose iodized oil TACE group （P〈0.05） ;Necrosis grades of tumor was negative correlated to the tumor metastasis. CONCLUSION：High dose iodized oil can induce more necrosis and inhibit intrahepatic and lung metastasis of transplanted VX2 liver tumor after TACE.
出处
《第四军医大学学报》
CAS
北大核心
2009年第14期1300-1302,共3页
Journal of the Fourth Military Medical University
基金
陕西省卫生厅自然科学基金(2005)
关键词
碘化油
化学栓塞
治疗性
肝肿瘤
肿瘤转移
iodized oil
chemoembolization, therapeutic
liver
neoplasms metastasis
