摘要
目的:观察国产替米沙坦治疗轻中度高血压的临床降压效果及安全性。方法:70例确诊为轻中度高血压病患者,随机分为治疗组(替米沙坦组)和对照组(厄贝沙坦组),前者34人,后者36人。每日早晨分别顿服替米沙坦40mg或厄贝沙坦75mg,根据血压调整剂量,连用8周。入选时与服药后第8周末测定血钾、肝功能、肾功能。结果:服药后第4周、第8周两观察组血压均较观察前显著降低(P<0.05,P<0.01),且替米沙坦组的降压作用较厄贝沙坦组明显(P<0.01)。到第8周末,治疗组与对照组降压总有效率分别达88.2%与86.1%,与观察开始前比较,第8周末两观察组的血钾、肝功能、肾功能均无明显改变。结论:国产替米沙坦对轻、中度高血压病患者有良好的降压效果,服用安全。
Objective： To observe the therapeutic effect of home-made telmisartan on patients with mild to moderate essential hypertension and the safety in clinic. Methods：Seventy patients with essential hypertension were randomly allocated to telmisartan group （ n = 34 ） and irbesartan group（controls,n = 36）. The patients received telmisartan or irbesartan in a dose of 40 mg or 75 mg,respectively,each morning for 8 weeks,with adjusted dose to the variation of blood pressure. The serum levels were examined on potassium,liver and renal function before and after the trial. Results ：The blood pressure in the both groups were decreased significantly after 4 and 8 weeks of therapy compared with that before the trial（P 〈 0. 05 ; P 〈0.01 ）. Telmisartan seemed more effective than irbersartan（ P 〈 0. 01 ）. By the end of the 8th week,88.2% and 86.1% of the patients responded to the medication, respectively, but the serum level of potassium,liver and renal function in both groups had no significant difference before and after the trial. Conclusion ： The national telmisartan is safe and effective in patients with mild to moderate essential hypertension .
出处
《皖南医学院学报》
CAS
2009年第3期200-202,共3页
Journal of Wannan Medical College
