摘要
目的探讨婴幼儿巨细胞病毒(CMV)性肺炎的临床特征、治疗情况及预后。方法对62例婴幼儿巨细胞病毒性肺炎的临床资料进行分析。结果临床表现为不同程度的气促、呼吸困难伴或不伴有发热、咳嗽、咳痰或仅有轻度咳嗽;血CMV-DNA阳性18例,尿液CMV-DNA阳性22例,痰CMV-DNA阳性62例,血CMV-IgM阳性16例,同时伴有肝功能损害22例;胸部X线正位片:间质性肺炎14例,絮状或斑片状渗出灶39例,肺纹理增粗、紊乱9例;腹部B超示肝脏肿大16例,肝脾肿大12例,脑干听觉诱发电位异常8例。所有患儿均予更昔洛韦抗病毒综合治疗,显效40例,有效22例,总有效率100%。结论使用实时荧光定量PCR技术、查痰CMV-DNA可提高巨细胞病毒肺炎的诊断,及时予更昔洛韦治疗,疗效好,值得临床推广。
Objective To discuss clinical manifestation,treatment and prognosis of infantile cytomegalovirus pneumonia. Methods Sixty-two cases with infantile cytomegalovirus pneumoniawere clinically analyzed. Results Be manifested in varying degrees of shortness of breath,dyspnea with or without fever,cough,expectoration,or only a mild cough. There were 18 cases of venous blood CMV-DNA positive,22 of urinary CMV-DNA positive,62 of respiratory secretions of children with CMV-DNA positive, 16 of blood CMV-IgM positive,accompanied by 22 of impaired liver function. For the chest X-ray films, there were 14 cases of interstitial pneumonia, 39 of patchy flocculent or exudative lesions, 9 of lung markings thickening and disorder. Abdominal B-showed 16 cases of hepatomegaly, hepatosplenomegaly in 12 cases, brainstem auditory evoked potential abnormalities in 8 cases. All patients were treated by combined treatment with ganciclovir antiviral. Among them 40 cases showed markedly effective and 22 did effective with a total effective rate of 100%. Conclusion Using real-time fluorescence quantitative PCR technology to search respiratory secretions CMV-DNA could improve cytomegalovirus pneumonia diagnosis, and timely given ganciclovir treatment showed an efficacy, and that is worthy to be popularized.
出处
《江西医学院学报》
2009年第6期82-83,86,共3页
Acta Academiae Medicinae Jiangxi
