摘要
目的分析Ⅲ、Ⅳ期非霍奇金淋巴瘤（NHL）患者的凝血功能变化及其意义。方法检测62例NHL患者与20名健康对照者凝血酶原时间（PT）、部分凝血活酶时间（APTT）、凝血酶时间（TT）和纤维蛋白原（FIB）水平。结果NHL患者APTT、FIB水平显著高于对照组，差异有统计学意义（P〈0．05、P〈0．01）。Ⅲ与Ⅳ期患者APTT、FIB水平显著高于对照组及Ⅱ期患者（P〈0．05、P〈0．01）；ⅢB、ⅣA和ⅣB患者FIB水平明显高于对照组及ⅢA患者（P〈0．01），但ⅢB、ⅣA和ⅣB患者之间FIB水平比较差异无统计学意义（P〉0．05）。结论NHL患者尤其是ⅢB-ⅣB期患者常伴有凝血功能紊乱，表现为高凝状态，需要监测凝血功能。
Objective To observe the alteration of coagulation function in the patients with stage Ⅲ- Ⅳ non-Hodgkin lymphoma and evaluate its clinical significance. Methods 62 patients with NHL and 20 healthy examiners were studied. The parameters of PT, APTT, TT and FIB in blood plasma were detected. Results The levels of APTT and FIB in NHL group were significantly higher than that in control group （P 〈 0.05 and〈0.01）, and in stage Ⅲ and Ⅳ NHL groups both were significantly higher than that in control group and stage Ⅱ group （P 〈 0.05 and 〈0.01）. The levels of FIB in ⅢB, ⅣA and ⅣB group were significantly higher than that in control group and mA group （P 〈0.01）, but there was no statistical significance among ⅢB, ⅣA and ⅣB group （P 〉0.05）.Conclusion The NHL patients especially Ⅲ B-ⅣB patients usually accompany with abnormal coagulation function and hypercoagulable states, and it＇s necessary to monitor their coagulation function.
出处
《白血病．淋巴瘤》
CAS
2009年第7期419-420,423,共3页
Journal of Leukemia & Lymphoma
