摘要
目的提高对HLA单倍体相合异基因造血干细胞移植后（allo—HSCT）植入综合征（ES）的认识，探讨其发病原因。方法报道1例慢性粒细胞白血病患者行母供女HLA半相合allo-HSCT后发生Es的临床表现和治疗经过。结果患者在allo-HSCT后＋2天即出现咳嗽，初为刺激性干咳，＋4天出现白色泡沫样痰、水肿、体重增加、非感染性发热、一过性精神症状，随着激素的应用临床症状逐渐改善，诊断为ES。结论ES是一种不同于急性移植物抗宿主病的移植后临床综合征，糖皮质激素治疗有效，早期正确诊断并积极治疗非常重要。
Objective To study the engraftment syndrome （ES） and the possible etiology after haploidentical allogeneic hematopoietic stem cell transplantation （allo-HSCT）. Methods The clinical manifestation, treatment and outcome of a chronic myeloid leukemia patient who after allo-HSCT were presented. Results The patient started to cough on day 2 after allo-HSCT, dry cough at beginning, white foam sputum, non-infectious fever, fluid retention, weight gain, transient encephalopathy on day 4. The clinical symptoms were improved after treatment with corticosteroids, in which ES was diagnosed. Conclusion ES is a series of clinical syndromes following transplantation which is different from acute graft versus host disease. It occurred after HSCT, and corticosteroids are often effective. Therefore early recognition and accurate diagnosis is very important.
出处
《白血病．淋巴瘤》
CAS
2009年第7期415-416,418,共3页
Journal of Leukemia & Lymphoma
