摘要
制备抗癌药顺铂和卡铂在水溶液中的降解产物-羟桥双核铂(Ⅱ)化合物,研究其化学结构.以顺铂为起始原料,通过水合和313 nm紫外光照射,分离出目标化合物.通过测定铂含量,ESI-MS,1H NMR和单晶X衍射分析测定其结构.所得到的化合物为以羟基搭桥的双核铂(Ⅱ)配合物,中心离子与2个氮原子和2个氧原子组成平面正方形,2个中心离子之间的距离为0.309 5 nm,有弱作用.2个配位平面的二面角为2.7°,几乎处于同一平面.2个硝酸根处于配位的外界.
To prepare and characterize the hydroxyl- bridged dimeric platinum compound, a degradation product of cisplatin in aqueous solution. The compound was prepared via aquation of cisplatin, followed by irradiation at 313 nm. The chemical structures were characterized by elemental analysis, ESI -MS, ^1H NMR, along with X - ray crystal structure. The compound was determined to be a dimeric platinum （Ⅱ） complex with two hydroxyl groups as its bridged ligand. There are two expected Pt （ Ⅱ） square planes. The angle formed between the planes is 2.7°, suggesting the two planes are actually in the same plane. The length of Pt - Pt is 3. 095 and two nitrate ions lies outside the coordinated sphere.
出处
《云南大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第4期389-392,共4页
Journal of Yunnan University(Natural Sciences Edition)
基金
国家自然科学基金资助项目(20861004)
云南省应用基础基金(重点项目)资助项目(2008CC020)
关键词
顺铂
水溶液
降解产物
合成
结构
cisplatin
aqueous solution
degradation product
synthesis
structure
