摘要
目的制备5-氟尿嘧啶凝胶微球实现结肠定位治疗的目的。方法选择滴制法制备海藻酸钙凝胶微球，并选择丙烯酸树脂水分散体为衣膜材料，采用流化床技术包衣，以微球圆整度、包封率、释放度为质量指标，对球芯滴制工艺和处方进行了单因素考察，通过正交设计筛选出最优处方。结果凝胶微球体外4h药物累积释放率〈15％，12h〉85％。结论按最优化处方工艺制得的5-氟尿嘧啶微球符合结肠定位制剂要求，且性质稳定。
Objective To prepare 5-FU loaded gels microspheres for colon-specific. Methods The calcium alginatc gels microspheres were prepared by drop method. The orthogonal test was used to optimize the core formulation, and the coating process was performed on a mini-fluidized bed spray coater with Eudragit S100. Results The drug releasing percentage of the coated gel beads was less than 15% in 4 hours and reached 85% in 12 hour. Conclusion The optimized method can be used to prepare 5-FU colon-specific gel microsphere successfully.
出处
《医学综述》
2009年第15期2352-2355,共4页
Medical Recapitulate
关键词
5-氟尿嘧啶
海藻酸钙凝胶微球
体外释放
5-fluorouracil
Calcium alginate gel microspheres
Colon specific
Release in vitro
