摘要
他汀类药物对冠心病二级预防拥有大量的临床循证医学数据。早期他汀类的研究主要是与安慰剂比较,对稳定性冠心病的疗效,结果令人振奋。进入新世纪以来,他汀对急性冠脉综合征的作用效果也充分得到研究。越早积极降脂,效果越佳。同时,对稳定性冠心病采取积极强化他汀降脂比常规他汀降脂可以取得更好的临床益处。除了临床终点性的研究之外,影像学研究上也发现强化他汀可以减缓粥样斑块进展,甚至可以逆转病变。对冠心病特殊人群如老年和女性患者,也应当进行积极降脂。
There are numerous evidence-based support for the secondary prevention_with statin. In the early time,clinical studies with statin focused on stable coronary artery disease. After entering the new millennium, the effect of statin on acute coronary syndrome was also confirmed. The early intensive lipid lowering treatment with statin benefit patients more than moderate lipid lowering therapy, in addition, clinical trials also found the benefit of intensive statin therapy compared with routine statin therapy in patients with stable coronary artery disease. The image studies demonstrated intensive statin therapy may slow or even reverse the progression of atheronla. A pro-active approach with statin to those under-represented population such as elderly and women patients is also recommended.
出处
《心血管病学进展》
CAS
2009年第4期535-538,共4页
Advances in Cardiovascular Diseases
关键词
他汀
冠心病
二级预防
statin
coronary artery disease
secondary prevention
