摘要
由乙氧甲叉基丙二酸二乙酯和相应的脒在碱性条件下合成了4-羟基-5-嘧啶甲酸乙酯和2-甲基-4-羟基-5-嘧啶甲酸乙酯,原料易得、操作步骤简单、反应条件温和,产率可分别达到80%和91%。
Starting from diethyl 2- （ ethoxymethylene ） malonate, the target molecules ethyl 4-hydroxypyrimidine-5-earboxylate and ethyl 4-hydroxy-2-methylpyrimidine-5-carboxylate were synthesized at a yield of 80% and 92%, respectively. The one-step method for synthesis of the target molecules was simple with a higher yield of target products as compared to the reported method.
出处
《化学试剂》
CAS
CSCD
北大核心
2009年第7期541-542,547,共3页
Chemical Reagents
基金
国家自然科学基金资助项目(20672043
2067-2044)
