摘要
目的探讨低剂量结合型雌激素（ＣＥ）和安宫黄体酮（ＭＰＡ）联合应用对骨代谢的影响。方法３４例绝经后妇女随机分为两组，试验组１７例，ＣＥ０．６２５ｍｇ与ＭＰＡ２ｍｇ隔日口服交替应用；对照组１７例，口服ＣＥ０．６２５ｍｇ／ｄ，每月连续服用２５ｄ，后１０ｄ加用ＭＰＡ４ｍｇ。两组均连续服用４周期，于用药前后分别测定血碱性磷酸酶（ＡＬＰ）及尿Ｃａ／Ｃｒ比值。结果实验组完成治疗者１６例，对照组完成治疗者１５例。治疗后两组ＡＬＰ无明显变化（Ｐ＞０．０５），尿Ｃａ／Ｃｒ均明显下降（Ｐ＜０．０５，Ｐ＜０．０１），两组治疗效果无明显差异（Ｐ＞０．０５）。结论绝经后妇女低剂量激素替代治疗（ＨＲＴ）对骨形成无作用，可抑制骨吸收，有效地防治绝经后妇女骨质疏松。
Objective To study the effects of lowdose hormonal replacement therapy (HRT) on the bone metabolism in postmenopausal women(PMW).Method 34 cases of postmenopausal women (PMW) were divided randomly into trail (17 cases) and control group (17 cases). The train group received lowdose estrogen and progestogen:conjugated estrogen(CE) 0.625 mg and medroxyprogesterone acetate(MPA) 2 mg QOD alternately. The control group was treated with CE 0.625 mg daily for 25 days in combination with cycle MPA 4mg daily ,the last 10 days for four cycles. Fasting urinary Ca/Cr and serum alkaline phosphatase (ALP) concentration were measured before and after treatment in all subjects.Results The results showed that in both groups, the fasting urinary Ca/Cr ratio reduced significanfly (P<0.05), while serum ALP were no significanfly after treatment. The changes of there parameters were not significantly in between the train group and the control group(P>0.05).Conclusion The lowdose hormonal replacement therapy could effectively reduced the bone absorption and prevent osteoporotic.
出处
《潍坊医学院学报》
1998年第2期85-86,共2页
Acta Academiae Medicinae Weifang
关键词
绝经后妇女
激素
替代治疗
骨代谢
postmenopausal women
bone metabolism
hormonal replacementtherapy
osteoporosis
