摘要
目的分析帕金森叠加综合征的临床特点、影像学特征,为临床诊断提供依据。方法回顾性分析10例帕金森叠加综合征患者的临床及影像学资料。结果诊断多系统萎缩(MSA)-C型5例,MSA P型2例,进行性核上性麻痹(PSP)3例。MSA-C型以小脑症状突出,MSA-P型以锥体外系症状表现为主,PSP以姿势异常、躯干僵直、核上性眼球运动障碍为主要表现。头颅MRI显示MSA-C型的主要病变在脑干、小脑,MSA-P型病变在壳核,PSP的主要病变在中脑。结论临床表现结合头颅MRI检查可提高帕金森叠加综合征的诊断率。脑干、小脑萎缩有助于MSA-C型诊断,壳核萎缩及壳核背外缘T2WI低信号支持MSA-P型诊断,中脑萎缩支持PSP诊断。
Objective To analyse clinical manifestations and neuroimage for correct diagnosis of the Parkinsonism plus syndromes. Methods 10 cases of Parkinsonism plus syndromes were retrospectively analysed in clinical and neuroimege materials. Results 7 cases were probably diagnosed as multipe system atrophy （MSA）, among which 5 cases were MSA-C, 2 cases were MSA-P; 3 cases were progressive supranuclear palsy （PSP）. Cerebellar signs were dominant clinic features in MSA-C; Extrapyramidal signs were apparent in MSA-P; The main clinical features of PSP were abnormal posture.body stiffness and supranuclear eye movement disorder. Brain MRI showed that main lesion of MSA-C were in the cerebellum, brainstem; MSA-P were in the putamen; PSP in the midbrain. Conclusions The diagnostic accordance rate of MSA, PSP can be elevated with correlation between clinical manifestations and brain MRL Atrophy of the brainstem and the cerebellum can be useful to the diagnosis of MSA-C, the putamen atrophy and T2WI low intensity of dorsolateral margin of the putamen will support the diagnosis of MSA-P. The midbrain atrophy can support the diagnosis of PSP.
出处
《中国神经免疫学和神经病学杂志》
CAS
2009年第4期251-253,共3页
Chinese Journal of Neuroimmunology and Neurology
关键词
帕金森叠加综合征
多系统萎缩
进行性核上性麻痹
Parkinsonism plus syndromes
multipe system atrophy
progressive supranuclear palsy
