摘要
目的研究睡眠呼吸暂停综合征（ＳＡＳ）对脑血流及脑血管疾病的影响。方法选择年龄、性别和基础疾病相配对，ＳＡＳ组３０例，对照组３２例。ＳＡＳ经多导睡眠监测仪检查而诊断。用阿克松多功能彩超仪，检测双侧大脑前、中、后动脉的血流速度和频谱形态。结果ＳＡＳ组与对照组收缩期血流峰值（ＶＳ），平均血流速度（ＶＭ），阻力指数（ＲＩ）等９项指标差异均有显著性（Ｐ＜０．０５～Ｐ＜０．０１），血流频谱形态异常ＳＡＳ组增多，并且ＶＳ、ＶＭ与呼吸暂停指数（ＡＩ）呈显著负相关（ｒ＝－０．４１３～－０６２８，Ｐ＜０．０５～００１），与ＳａＯ２呈显著正相关（ｒ＝０．４３５～０７１２，Ｐ＜０．０５～００１）。结论ＳＡＳ患者脑血流速度减慢，频谱形态异常增多，提示ＳＡＳ可促发脑供血不足，脑动脉硬化。
Objective To study the cerebral blood flow in patients with and without sleep apnea syndrome (SAS). Method Thirty patients with SAS were studied, with 32 patients without SAS as controls. The age, sex and baseline diseases were comparable between these two groups. Subjects were studied by polysomnography and transcranial Doppler ultrasonography. The systolic (VS) and mean (VM) cerebral blood flow velocities, resistent index (RI), and frequency spectral shape were determined. Anterior, middle and posterior cerebral arteries were examined by transcranial Doppler ultrasonography in all patients. Result VS and VM were significantly lower in patients with SAS than those in the control subjects (P<0.05 and P<0.01). RI of the right PCA in SAS patients (0.56±0.06) was significantly higher than that in the controls (0.48±0.09, P<0.05). Changes in the cerebral blood flow frequency spectral shape were remarkably increased in the SAS group as compared to control group. VS and VM were negatively correlated with apnea index (r=-0.413 and -0.628, P<0.05 and 0.01), but positively correlated with SaO2 (r=0.435 and 0.712, P<0.05 and 0.01). Conclusion The results suggest that SAS patients have decreased cerebral blood flow velocities and more frequency shape abnormalities. These may decrease cerebral perfusions, and lead to cerebral atherosclerosis and stroke.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1998年第8期484-485,共2页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
"九五"军队医药卫生科研基金
