摘要
目的调查非洒精性脂肪性肝病（NAFLD）发病的影响因素，为预防NAFLD的发生提供可靠的流行病学依据。方法采用病例对照研究方法，对福建医科大学附属协和医院2007年18月体检确诊的NAFI．D患者385例和同期的体检健康人群825人进行调查。自制调查表收集两组一般情况、生活方式、饮食习惯、疾病既往史及生物化学检查结果，并对过程进行质量控制。两组问均衡检验采用f检验和x^2检验；单因素分析采用x^2检验；采用非条件Logistic逐步回归分析筛选变量，找出NAFLD的影响因素。结果两组在饮洒量（g／周）、是否喝茶、是否吸烟、运动指数、韭餐速度、应酬频率、食用油种类、是否食用海产品、是否有脂肪肝家族史及是否有高血压、血糖增高、血脂异常、ALT增高、AST增高、高尿酸血症、肥胖、高密度脂蛋白降低、低密度脂蛋白增高】8个方面的差异有统计学意义（P值均〈0．05）。非条件Logistic逐步回归分析结果显示，以上18个因素中有12个因素进入模型，其中肥胖（OR=6．35）、高血压（OR=3．82）、血脂异常（OR=2．95）、高密度脂蛋白降低（OR=2．85）、高血糖（OR=2．82）、ALT增高（OR=2．80）、高尿酸血症（ON=2．35）、HBsAg阳性（OR=1．99）、脂肪肝家族史（OR=1．79）及常吃海产品（OR=1．58）是NAFLD的危险凶素，而饮茶（OR=0．72）和经常运动（OR=0．90）则是NAFLD的保护因素。结论影响NAFLD发病的因素有多种，主要是生活方式，与遗传因素也有关。
Objective To investigate the influencing factors of nonalcoholic fatty liver disease （NAFLD）. Methods A hospital-based case-control study was conducted in patients with NAFLD and controls without NAFLD in a hospital from January to August in 2007. All data were analyzed by SPSS 13.0 software. Results One-way analysis of variance found that the two groups were significantly different in cigarette smoking, alcohol and tea comsumption, movement index, speed of food intake, frequency of social engagement, kinds of edible oil, marine products, family history of NAFLD, hypertension, higher blood sugar, abnormality of blood fat, higher level of ALT, higher level ofAST, hyperuricemia, obesity, decrease of high density lipoprotein （HDL）, and increase of low density lipoprotein. By non-conditional logistic stepwise regression analysis, 12 of 18 factors were used to construct a model, ten of which were the risk factors and two were protective factors of NAFLD. Risk factors included obesity （OR = 6.35）, hypertension（OR = 3.82）, dyslipidemia （OR - 2.95）, decrease of HDL （OR = 2.85）, hyperglycemia （OR = 2.82）, increase of ALT （OR =2.80）, hyperuricemia （OR = 2.35）, HBsAg positive （OR = 1.99）, family history of fatty liver （OR = 1.79） and frequently intake of marine products （OR=1.58）, and protective factors included tea drinking （OR = 0.72） and exercise （OR = 0.90）. Conclusions There are many influencing factors of NAFLD, and life styles are the key factors. Genetic background may also play some roles in NAFLD.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2009年第7期535-539,共5页
Chinese Journal of Hepatology
基金
高等学校全国优秀博士学位论文作者专项资金（200359）
福建省青年科技人才创新项目（2001J058）
2006年福建省高等学校科技创新团队培育计划（FMU-RT001）
关键词
脂肪肝
危险因素
病例对照研究
Fatty liver
Risk factors
Case-control studies
