摘要
目的探讨在癫痫病人中用卡马西平、托吡酯替换苯妥英钠、苯巴比妥的临床效果。方法将62例原先使用苯妥英钠、苯巴比妥的癫痫病人，采用首选卡马西平或托吡酯进行渐进缓慢先添加新药、后撤退原用药的方法，对苯妥英钠、苯巴比妥进行替换。结果30例病人完全由卡马西平单药替换，11例病人完全由托吡酯单药替换。撤换时间为3～6个月的复发率为38％，而撤换时间为7～12个月的复发率为18％，两者差异有显著性（P〈0．05）。结论卡马西平、托吡酯均可推荐作为选择的药物对苯妥英钠、苯巴比妥进行替换。
Objective To study the effects of withdrawing phenytoin and phenobarbital with carbamazepine or topiramate. Methods 62 patients with chronic cryptogenic or symptomatic localized epilepsy were treated with carbamazepine or topiramate instead of phenytoin. Result The drug of 30 and 11 patients were thoroughly replaced with carbamazepine and topiramate, respectively. The recurrent rates of replacement for 3 to 6 months and for 7 to 12 months were 38% and 18%, respectively （P〈0.05）. Conclusion Carbamazepine or topiramate is recommended as drugs for replacement of phenytoin and phenobarbitone.
出处
《西部医学》
2009年第7期1125-1126,1129,共3页
Medical Journal of West China
