期刊文献+

自身免疫性甲状腺疾病与TNF-α/IL-6比值的关系研究 被引量:4

下载PDF
导出
摘要 目的研究细胞因子Th1/Th2平衡与AITD的关系。方法检测71例GD、35例HT患者及36例对照者的血清TNF-α、IL-6和甲状腺激素及相关抗体水平。结果各组TNF-α、IL-6显著高于对照组。GD组TNF-α/IL-6比值显著低于对照组,HT组TNF-α/IL-6比值显著高于对照组。结论GD以IL-6升高为主,提示Th2介导的体液免疫占优势;HT以TNF-α升高为主,提示Th1介导的细胞免疫占优势。
出处 《山东医药》 CAS 北大核心 2009年第25期78-79,共2页 Shandong Medical Journal
  • 相关文献

参考文献4

二级参考文献25

  • 1甄真,裴,王麟士,刘金星,赵彩彦,周俊英.病毒性肝炎患者血清IL-6,TNF,SIL-2R的变化[J].中华传染病杂志,1996,14(3):170-171. 被引量:33
  • 2蔡东升,刘超.细胞因子与甲状腺[J].国外医学(内分泌学分册),1997,17(1):7-10. 被引量:33
  • 3Wenisch C, Myskiw D, Gessi A, et al. Circulating salectrts , inter cellular adhesion molecule- 1, and vascular cell adhesion molecule-1 in hyperthyroidism [J]. Clin Endocrinol Metab, 1995, 80(7):2122. 被引量:1
  • 4Barthlena L. Interleukin-6 and thethyroid[J]. Eur J Endocrinol,1995, 132:386. 被引量:1
  • 5Yamazaki K, Yamamoto E, Kanaji Y, et al. Interleukin - 6 inhibits thyroid function in the presence of soluble IL - 6 receptor in cultured human thyroid follicles [J]. Endocrinology, 1996, 137:4857. 被引量:1
  • 6Onoda N, Tsuahima T Isozaki O, et al. Effect of IL- 6, hypothalamic- pituitary- thyroid axis inrat [A]. NAGATAKI S, Mori Torizuka K. 80years of Hashimoto's disease[M]. Amsterdam: Eserier Science Publisher, 1993. 355-359. 被引量:1
  • 7Salvi M, Pedrazzoni M, Girasole G. Serum concentrations of proinflammatory cytokines in Graves disease: effect treatment, thyroid function, ophthalmopathy and cigarette smoking [J]. Eur J Endocrinol,2000,143(2): 197 - 202. 被引量:1
  • 8Celik I. Serum levels of interleukin - 6 and tumornerosis factor in hyperthperthyroid patients before and after propythiouracil treatment[J]. Eur Endocrinol, 1995,132:668. 被引量:1
  • 9Yu S,Sharp GC,Braley-Mullen H.Thyrocytes responding to IFN-gamma are essential for development of lymphocytic spontaneous autoimmune thyroiditis and inhibition of thyrocyte hyperplasia[ J].J Immunol,2006,176(2):1259-1265. 被引量:1
  • 10Yu S,Sharp GC,Braley-Mullen H.Thyroid epithelial cell hyperplasia in IFN-gamma deficient NOD.H-2h4 mice[ J].Clin Immunol,2006,118(1):92-100. 被引量:1

共引文献44

同被引文献37

引证文献4

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部