摘要
目的探讨功率多普勒成像(PDI)与微血管密度(MVD)、血管内皮生长因子(VEGF)检测乳腺肿块血管形成的相关性并评价其临床应用价值。方法选择2005年9月～2006年3月山西医科大学第二医院乳腺科乳腺肿块患者39例,均为女性,年龄22～71岁,平均年龄44.5岁(良性组39.2岁,恶性组48.8岁)。良性17例,恶性22例。对全部患者行超声检测,采用计算机Photoshop7.0软件对肿块功率多普勒血流信号进行定量分析,测定彩色像素密度(CPD);用抗CD34因子及抗VEGF因子免疫组织化学染色测定肿块MVD及VEGF阳性表达率,对CPD与MVD的相关性进行分析。结果恶性组CPD、MVD及VEGF阳性表达率较良性组高,两者差异有显著统计学意义(P<0.01),CPD与MVD间具有良好相关性(r=0.822,P<0.01)。结论PDI所测CPD可较好反映乳腺肿块血流情况,有助于乳腺疾病的鉴别诊断,与MVD计数、VEGF测定相结合,能全面反映肿瘤血管生成状态。
Objective To study the correlation of power Doppler imaging（PD1） and microvessel density（MVD）, vascular endothelial growth factor（VEGF） with breast masses angiogensis and evaluate its clinical application. Methods Power Doppler uhrasound was performed on 39 patients with breast mass; all patients were female, 22 - 71 years, mean age 44.5 years, 17 of them in benign group, mean age 39.2 years, 22 of them in malignant group, mean age 48.8 years. Color pixel density（CPD） with computer-assist power Doppler flow signal were analyzed. The MVD and VEGF were calculated in surgical specimen after immunohistochemical staining with anti-factor CD34 and VEGF. The correlation between CPD and MVD was analyzed. Results The level of CPD, MVD and VEGF in malignant group were higher than those in benign group. There were significant differences between 2 groups （P 〈 0.01）, and close correlation was shown between CPD and MVD （r = 0.822 ,P 〈 0.01 ）. Conclusion Power Doppler CPD as an indicator for breast mass angiogenesis is useful for differential diagnosis of breast disorders. The intratumoral vascularization patterns can be comprehensively evaluated by PDI quantitative assessement combined with MVD and VEGF.
出处
《生物医学工程与临床》
CAS
2009年第4期311-314,共4页
Biomedical Engineering and Clinical Medicine
关键词
乳腺
功率多普勒成像
彩色像素密度
微血管密度
血管内皮生长因子
mammary glands
power Doppler imaging
color pixel density
microvessel density
vascular endothelial growth factor
